Together this difference in types of T-cell-dependent t1IFN immunity for different <i>Cryptococcus</i> species suggests a possible mechanism by which HIV infection may select against <i>C. gattii</i> but not <i>C. neoformans</i><b>IMPORTANCE</b><i>Cryptococcus neoformans</i> and <i>Cryptococcus gattii</i> cause fatal infection in immunodeficient and immunocompetent individuals.
Interestingly, suboptimal APC response observed in LVR children at 6-9 mo of age characterized by significantly ( P < 0.05) low basal MHC II expression, low R848 induced IRF7 fold change, as well as low IFN-α, IL-12p70 and IL-1β levels, came to parity with normal vaccine responders by 12-15 mo of age, suggesting that the observed immune deficiency in LVR children may be the result of delayed maturation of immune system.
Enhanced innate antiviral gene expression, IFN-α, and cytolytic responses are predictive of mucosal immune recovery during simian immunodeficiency virus infection.
With any of 15 virus isolates, tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6, IFN-omega or IFN-beta are not detected nor the mRNA expressed in HIV-infected or uninfected monocytes.