Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8 		0.100 Biomarker phenotype HPO
Entrez Id: 31
Gene Symbol: ACACA
ACACA 		0.200 Biomarker phenotype RGD These studies suggest that pharmacological inhibition of Acc1 and -2 may be a novel approach in the treatment of NAFLD and hepatic insulin resistance. 16485039 2006
Entrez Id: 32
Gene Symbol: ACACB
ACACB 		0.500 Biomarker phenotype CTD_human Impact of dietary fat quantity and quality on skeletal muscle fatty acid metabolism in subjects with the metabolic syndrome. 22658938 2012
Entrez Id: 32
Gene Symbol: ACACB
ACACB 		0.500 Biomarker phenotype RGD We used a diet-induced rat model of nonalcoholic fatty liver disease (NAFLD) and hepatic insulin resistance to explore the impact of suppressing Acc1, Acc2, or both Acc1 and Acc2 on hepatic lipid levels and insulin sensitivity. 16485039 2006
Entrez Id: 109
Gene Symbol: ADCY3
ADCY3 		0.100 Biomarker phenotype HPO
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ 		0.500 Therapeutic phenotype RGD Dietary intake of medium- and long-chain triacylglycerols ameliorates insulin resistance in rats fed a high-fat diet. 21872431 2012
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ 		0.500 Therapeutic phenotype CTD_human Dual acting and pan-PPAR activators as potential anti-diabetic therapies. 21484566 2011
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ 		0.500 Biomarker phenotype RGD The severe insulin resistance predominantly in epididymal adipose tissue of WOKW rats is associated with a 10-fold decrease in adipocyte adiponectin gene expression, decreased Ppar gamma, but increased Foxo1 gene expression compared to DA rats. 16041833 2006
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ 		0.500 Therapeutic phenotype CTD_human Adiponectin is an adipocyte-derived protein that acts to reduce insulin resistance in the liver and muscle and also inhibits atherosclerosis. 18931039 2009
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ 		0.500 Therapeutic phenotype RGD Treatment with heme arginate alleviates adipose tissue inflammation and improves insulin sensitivity and glucose metabolism in a rat model of Human primary aldosteronism. 23089228 2012
Entrez Id: 134
Gene Symbol: ADORA1
ADORA1 		0.200 Therapeutic phenotype RGD Characterization of adenosine-A1 receptor-mediated antilipolysis in rats by tissue microdialysis, 1H-spectroscopy, and glucose clamp studies. 15220221 2004
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2 		0.500 Biomarker phenotype RGD Attenuation of insulin resistance by chronic beta2-adrenergic agonist treatment possible muscle specific contributions. 11510954 2001
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2 		0.500 Biomarker phenotype CTD_human The beta2 adrenergic receptor Gln27Glu polymorphism affects insulin resistance in patients with heart failure: possible modulation by choice of beta blocker. 19034036 2008
Entrez Id: 10555
Gene Symbol: AGPAT2
AGPAT2 		0.100 Biomarker phenotype HPO
Entrez Id: 186
Gene Symbol: AGTR2
AGTR2 		0.200 Biomarker phenotype RGD We found that the FDR developed insulin resistance and downregulated both AT(2)R neuronal function and phosphorylated Akt expression in dorsal root ganglia (DRG) neurons. 22357959 2012
Entrez Id: 196
Gene Symbol: AHR
AHR 		0.300 Biomarker phenotype CTD_human Effects of Adipocyte Aryl Hydrocarbon Receptor Deficiency on PCB-Induced Disruption of Glucose Homeostasis in Lean and Obese Mice. 25734695 2015
Entrez Id: 208
Gene Symbol: AKT2
AKT2 		0.100 Biomarker phenotype HPO
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2 		0.200 Therapeutic phenotype RGD Resveratrol attenuates excessive ethanol exposure induced insulin resistance in rats via improving NAD 28688179 2017
Entrez Id: 7840
Gene Symbol: ALMS1
ALMS1 		0.100 Biomarker phenotype HPO
Entrez Id: 8862
Gene Symbol: APLN
APLN 		0.200 Biomarker phenotype RGD These associations evidence a possible role for apelin in the excessive weight gain induced by high-fat feeding and increased adiposity, insulin-resistance, liver oxidative stress and inflammation. 17594060 2007
Entrez Id: 345
Gene Symbol: APOC3
APOC3 		0.200 Therapeutic phenotype RGD Isotretinoin and fenofibrate induce adiposity with distinct effect on metabolic profile in a rat model of the insulin resistance syndrome. 15007394 2004
Entrez Id: 367
Gene Symbol: AR
AR 		0.300 Biomarker phenotype CTD_human The interpretation of the association between testosterone and IR seems to require consideration of the AR CAG repeat polymorphism. 21444647 2011
Entrez Id: 383
Gene Symbol: ARG1
ARG1 		0.200 Biomarker phenotype RGD Insulin resistance induced by a high-fructose diet potentiates thioacetamide hepatotoxicity. 20593143 2010
Entrez Id: 55252
Gene Symbol: ASXL2
ASXL2 		0.100 CausalMutation phenotype CLINVAR
Entrez Id: 472
Gene Symbol: ATM
ATM 		0.200 Biomarker phenotype RGD The decreased ATM expression suggests that ATM is involved in the development of insulin resistance through down-regulation of Akt activity. 18534819 2008