| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | Cerebrospinal Fluid Total and Phosphorylated α-Synuclein in Patients with Creutzfeldt-Jakob Disease and Synucleinopathy. | 30136097 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | We applied RT-QuIC assay to detect α-synuclein aggregates in cerebrospinal fluid (CSF) of patients with suspected Creutzfeldt-Jakob disease who had a neuropathological diagnosis of dementia with Lewy bodies (DLB) (n = 7), other neurodegenerative diseases with α-synuclein mixed pathology (n = 20), or without Lewy-related pathology (n = 49). | 31599499 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Thus, PrP<sup>Sc</sup> in CJD affects the vagus nerve analogously to α-synuclein in Parkinson disease. | 30801763 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Cerebrospinal fluid α-synuclein was quantified in a total of 188 sporadic Creutzfeldt-Jakob disease and non-Creutzfeldt-Jakob-disease cases to determine sensitivity and specificity values and lot-to-lot variability. | 30294658 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Detection of α-synuclein in the CSF of patients with suspected CJD is a valuable diagnostic test reaching almost full discrimination from non-prion disease cases. | 27870938 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | This observation has pathological relevance, since several reported case studies show that the accumulation of α-Syn amyloid deposits in Creutzfeldt-Jakob disease patients is accompanied by a longer disease course. | 28855681 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | Remarkably, α-synuclein is the first new human prion to be identified, to our knowledge, since the discovery a half century ago that CJD was transmissible. | 26324905 | 2015 | ||||
|
0.080 | Biomarker | disease | BEFREE | Previous reports have shown that in Creutzfeldt-Jakob disease and scrapie, α-synuclein accumulates near PrP(Sc) deposits. | 22460692 | 2013 |