Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | IL-27 protects against renal I/R injury by activating STAT3, suggesting that IL-27 may represent a novel strategy for the treatment of AKI. | 31722339 | 2019 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | In conclusion, our results indicate that MaR1 is able to reduce neutrophil infiltration and inhibit nuclear factor-kappa B/signal transducer and activator of transcriptor 3/mitogen-activated protein kinase (NF-κB/STAT3/MAPK) activity and regulate inflammatory cytokine level to inhibit inflammatory response and thereby weaken sepsis-associated AKI in mice. | 31787899 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | AG490 alleviated DDP-induced AKI in lung cancer mice with improved oxidative stress and inflammation, and the suppression of JAK2/STAT3 pathway. | 31250048 | 2019 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | G31P also inhibited the activation of JAK2, STAT3 and NF-κB in AKI mice. | 31084615 | 2019 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Besides, the expression levels of HIPK2 and p-STAT3 were suppressed in Wa-2 mice during VAN-induced transition of AKI to CKD. | 31131063 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | The aim of this study is to evaluate the therapeutic effects of HO-1 overexpressed mesenchymal stem cells (MSCs) in AKI and investigate the role of JAK/stat3 pathway in the treatment strategy. | 31719896 | 2018 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Preliminary Report on the Association Between STAT3 Polymorphisms and Susceptibility to Acute Kidney Injury After Cardiopulmonary Bypass. | 29846833 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Endothelial STAT3 Modulates Protective Mechanisms in a Mouse Ischemia-Reperfusion Model of Acute Kidney Injury. | 29181415 | 2017 |