Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.380 | AlteredExpression | disease | BEFREE | The high TLR2 expression associated with IL-10 levels, in the leprosy reaction groups, may be hypothetically related to the formation of TLR2/2 homodimers and/or TLR2/6 heterodimers linked to evasion mechanisms in downgrading reactions and pathophysiology of ENL. | 31781675 | 2019 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | Our results show an association between the T allele of rs3804099 at the TLR2 gene and increased risk for leprosy per se [Odds ratio (OR) = 1.296, p = 0,022]. | 28327786 | 2017 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | High IL10 producing allele of TLR2 microsatellite might predispose house hold contacts to leprosy. | 23619473 | 2013 | ||||
|
0.380 | Biomarker | disease | BEFREE | The data support the possibility of an important role for TLR2 and TLR4 in the pathogenesis of this important complication of leprosy. | 22348338 | 2012 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | The goal of the present study was to assess the effect of Toll-like receptor 2 (TLR2) polymorphisms on susceptibility to and clinical presentation of leprosy. | 18177245 | 2008 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | TLR2 Arg677Trp polymorphism in leprosy: revisited. | 15726416 | 2005 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | Polymorphisms of TLR2 (which recognizes mycobacterial components in concert with CD14) are involved in the pattern of response to mycobacteria, and in the type of leprosy that develops. | 14501431 | 2003 | ||||
|
0.380 | Biomarker | disease | BEFREE | Here, the events triggered by TLR2 in response to cell lysate of Mycobacterium leprae(MLL), the causative agent of leprosy, were investigated. | 12445799 | 2002 | ||||
|
0.380 | Biomarker | disease | CTD_human |