|
IGHV1-69
|
0.100 |
Biomarker
|
disease |
BEFREE |
Subset #6 (IGHV1-69/IGKV3-20) is less aggressive compared to subset #8 (IGHV4-39/IGKV1(D)-39) which has the highest risk for Richter's transformation among all CLL.
|
30447004 |
2019 |
|
IGHV1-69
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For example, patients with IGHV1-69 clones tend to be U-CLL with a poor prognosis, whereas patients with IGHV3-30 tend to be M-CLL and have a better prognosis.
|
28125682 |
2017 |
|
IGHV1-69
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A significantly lower usage of IGHV1-69 and IGHV1-2 was documented, with comparable IGHV3-21 frequency (3% Chinese vs 3.8% Italian CLL).
|
26943037 |
2016 |
|
IGHV1-69
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
By contrast, IGHV1-69 was expressed at a higher frequency in unmutated CLL patients.
|
24790994 |
2014 |
|
IGHV1-69
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data also provided new evidence supporting the prognostic relevance of separate IGHV genes or stereotyped BCR in CLL, namely: (a) a restricted non-mutated (UM) IGHV gene repertoire in CLL patients with autoimmune haemolytic anaemia (AIHA) (more frequent expression of UM IGHV1-69, IGHV3-11 and IGHV4-59 genes, P = 0.001), a shorter period of AIHA development for expressors of these genes (P = 0.001) and a tendency towards expression of a stereotypic HCDR3 (P = 0.029), (b) a high incidence of second solid tumour development in IGHV3-21-expressing patients (P = 0.005) and (c) differences in overall survival (OS) of UM CLL patients depending on the BCR structure.
|
21503826 |
2012 |
|
IGHV1-69
|
0.100 |
Biomarker
|
disease |
BEFREE |
The normal IGHV1-69-derived B-cell repertoire contains stereotypic patterns characteristic of unmutated CLL.
|
19887677 |
2010 |
|
IGHV1-69
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In comparison with patients using alternative immunoglobulin heavy-chain variable (IGHV) genes, patients with IgHV1-69 CLLs more often presented at advanced stage, lacked somatic hypermutation (unmutated cases, 87% vs. 35%; P = .00001), and expressed unfavorable biologic characteristics.
|
19858060 |
2009 |
|
IGHV1-69
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
IGHV1-69 gene expression was again quite low in our cohort, found in only two patients: one with chronic lymphocytic leukemia and the other with splenic marginal zone lymphoma.
|
19220298 |
2009 |
|
IGHV1-69
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To conclude, we present data confirming that IgHV1-69 gene rearrangements in CLL are not exclusively associated with unmutated IgHV status.
|
18398745 |
2008 |
|
IGHV1-69
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the immunoglobulin (Ig) variable heavy (IGHV) and variable light chain genes used by leukemia cells of 258 unrelated patients with chronic lymphocytic leukemia (CLL) found to express unmutated Ig heavy chains (IgH) encoded by a 51p1 allele of IGHV1-69 among 1846 CLL patients examined.
|
17675554 |
2008 |