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LOC390714
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Distinct immunoglobulin heavy chain variable region gene repertoire and lower frequency of del(11q) in Taiwanese patients with chronic lymphocytic leukaemia.
|
31230372 |
2019 |
|
LOC390714
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The different types of drug resistance encountered in chronic lymphocytic leukemia (CLL) cannot be fully accounted for by the 17p deletion (and/or TP53 mutation), a complex karyotype (CK), immunoglobulin heavy-chain variable region genes (IGHV) status and gene mutations.
|
31066214 |
2019 |
|
LOC390714
|
0.100 |
Biomarker
|
disease |
BEFREE |
Similarly, the immunoglobulin heavy chain variable region repertoire was distinct from those reported in CLL or MZL.
|
31590326 |
2019 |
|
LOC390714
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The abnormal expression of miRNAs may play critical roles in the occurrence, development and prognosis of chronic lymphocytic leukemia (CLL), with potential ethnic differences being involved. p53 and immunoglobulin heavy chain variable region gene (IGVH) mutations were monitored and miRNA profile screening of CD19 <sup>+</sup> cells from Uygur CLL patients was performed, analyzed by miRNA arrays and verified using real-time PCR.
|
31425738 |
2019 |
|
LOC390714
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Importantly, we confirmed by multivariate analysis that this was independent of IgHV mutational status or subset #2 stereotyped receptor (<i>P</i> < 0.0001).<b>Conclusions:</b> We have demonstrated for the first time that a light chain can affect CLL prognosis and that IgLV3-21 light chain usage defines a new subgroup of CLL patients with poor prognosis.<i></i>.
|
29945996 |
2018 |
|
LOC390714
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between immunoglobulin heavy-chain variable region mutational status and isolated favorable baseline genomic aberrations in chronic lymphocytic leukemia.
|
28641468 |
2018 |
|
LOC390714
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Both CLL and MCL include 2 major molecular subtypes that seem to derive from antigen-experienced CD5<sup>+</sup> B cells that retain a naive or memory-like epigenetic signature and carry a variable load of immunoglobulin heavy-chain variable region somatic mutations from truly unmutated to highly mutated, respectively.
|
29666114 |
2018 |
|
LOC390714
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
In T-cell lymphomas, anaplastic large-cell lymphoma is defined by mutually exclusive rearrangements of <i>ALK</i>, <i>DUSP22/IRF4</i>, and <i>TP63</i> Genetic alterations affecting <i>TP53</i> and the mutational status of the immunoglobulin heavy-chain variable region are important in clinical management of chronic lymphocytic leukemia.
|
28600336 |
2017 |
|
LOC390714
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunoglobulin heavy chain variable region gene repertoire and B-cell receptor stereotypes in Indian patients with chronic lymphocytic leukemia.
|
26942309 |
2016 |
|
LOC390714
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In chronic lymphocytic leukemia (CLL), patients with unmutated immunoglobulin heavy chain variable region gene (UM-CLL) have worse outcomes than mutated CLL (M-CLL) following chemotherapy or chemoimmunotherapy.
|
26717038 |
2016 |
|
LOC390714
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this systematic review, we examined the role of immunoglobulin heavy-chain variable region gene (IGHV) mutation status and genetic abnormalities determined by interphase fluorescence in situ hybridization (FISH) in patients with newly diagnosed CLL.
|
26841802 |
2016 |
|
LOC390714
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Second, we combined miRNA and gene expression data to identify putative miRNA functional networks. miRNA profiling showed distinctive patterns of regulation after stimulation in leukemic versus normal B lymphocytes and identified a differential responsiveness to BCR engagement in CLL subgroups according to the immunoglobulin heavy chain variable region mutational status and clinical outcome.
|
25645730 |
2015 |
|
LOC390714
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Based on the expression of 3521 identified proteins, principal component analysis separated CLL samples into two groups corresponding to immunoglobulin heavy chain variable region mutational status.
|
25645933 |
2015 |
|
LOC390714
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The relative expression levels of certain microRNAs (miRNAs) correlate with known prognostic markers in chronic lymphocytic leukemia (CLL), such as leukemia-cell expression of zeta-associated protein of 70 kDa (ZAP-70), use of unmutated immunoglobulin heavy-chain variable region genes (IGHV), chromosomal abnormalities or dysfunctional p53.
|
23597135 |
2013 |
|
LOC390714
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the t(14;18) in chronic lymphocytic leukemia is associated with relatively young age at diagnosis, mutated immunoglobulin heavy chain variable region genes, and a clinical course that usually requires chemotherapy.
|
23084581 |
2013 |
|
LOC390714
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We previously identified LDOC1 as one of the most significantly differentially expressed genes in untreated chronic lymphocytic leukemia (CLL) patients with respect to the somatic mutation status of the immunoglobulin heavy-chain variable region genes.
|
21310924 |
2011 |
|
LOC390714
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Importance of immunoglobulin heavy chain variable region mutational status in del(13q) chronic lymphocytic leukemia.
|
21851216 |
2011 |
|
LOC390714
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the correlation between well-established biological parameters of prognostic relevance in B-cell chronic lymphocytic leukemia (CLL) [i.e. mutational status of the immunoglobulin heavy chain variable region (IgVH), ZAP-70 and CD38 expression] and serum levels of B cell-activating factor (BAFF of the TNF family) by evaluating the impact of these variables on the time to first treatment (TFT) in a series of 169 previously untreated CLL patients in Binet stage A.
|
20546021 |
2010 |
|
LOC390714
|
0.100 |
Biomarker
|
disease |
BEFREE |
Clinical laboratory analysis of immunoglobulin heavy chain variable region genes for chronic lymphocytic leukemia prognosis.
|
20110453 |
2010 |
|
LOC390714
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It was showed that LPL expression correlates with IgVH mutational status and other clinical or laboratory prognostic factors, and might be applied for the assessment of prognosis in patients with CLL.
|
18616755 |
2009 |
|
LOC390714
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunoglobulin heavy chain variable region gene usage and mutational status of the leukemic B cells in Iranian patients with chronic lymphocytic leukemia.
|
19824994 |
2009 |
|
LOC390714
|
0.100 |
Biomarker
|
disease |
BEFREE |
Studies of familial CLL have suggested that the disease features are largely similar to sporadic CLL, although recent data suggest that familial CLL may more commonly show somatic hypermutation of the immunoglobulin heavy-chain variable region, suggesting a more indolent disease course.
|
19802369 |
2008 |
|
LOC390714
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The correlation between well-established biological parameters of prognostic relevance in B-cell chronic lymphocytic leukaemia (CLL) [i.e., mutational status of the immunoglobulin heavy chain variable region (IgV(H)), ZAP-70- and CD38-expression] and adiponectin serum concentration was evaluated in a cohort of 69 previously untreated Binet stage A CLL patients.
|
18818986 |
2008 |
|
LOC390714
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, novel parameters such as defects detectable on fluorescence in situ hybridization (FISH), expression levels of CD38 and ZAP-70, and immunoglobulin heavy-chain variable region status can add significant prognostic information about a given patient with CLL.
|
20425388 |
2007 |
|
LOC390714
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
On the other hand, in CLL cases that use unmutated immunoglobulin heavy-chain variable-region genes (IgV(H)) or have high-level expression of the 70-kD zeta-associated protein (ZAP-70) have high levels of TCL1 due to low-level expression of miR-29 and miR-181, which directly target this oncogene.
|
17707831 |
2007 |