Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker disease BEFREE From these observations it appears that overexpression without gene amplification of mdr-1/P-170 may be one mechanism of clinical drug resistance in ALL. 2765667 1989
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 AlteredExpression disease BEFREE MDR1 gene expression was examined in acute leukemia cells from 75 Japanese patients at diagnosis (50 with acute myeloblastic leukemia [AML]: 10 M1, 18 M2, 5 M3, 8 M4, 9 M5; 25 with acute lymphoblastic leukemia [ALL]: 13 B-precursor, 12 T-lineage). 7694687 1993
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 AlteredExpression disease BEFREE We found a concomitant increase in mdr1 and mrp gene expression combined with a decreased expression of topoisomerase II alpha in the course of the second relapse of an acute lymphoblastic leukemia (ALL). 7914748 1994
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 AlteredExpression disease BEFREE These results imply that malignant cells from all childhood AMKL might express the mdr-1/P-glycoprotein. 8590843 1995
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 AlteredExpression disease BEFREE In order to investigate the phenomenon of multidrug resistance as a possible mechanism for poor response to treatment in patients with acute lymphoblastic leukemia (ALL) from India, a series of 32 cases of de novo untreated ALLs were analyzed by a cDNA-PCR approach to estimate the relative mRNA levels of the MDR-associated genes encoding MDR1, MRP, GSTpi, and GSTmu. 9671132 1998
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 AlteredExpression disease BEFREE We found a high frequency of MDR1 gene expression: 10 out of 20 with de novo acute myeloid leukemia (AML), 8 out of 17 with de novo acute lymphoblastic leukemia (ALL), and none of the 3 with de novo acute mixed leukemia, were MDR1 mRNA-positive. 9886170 1998
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 AlteredExpression disease BEFREE We studied the expression of P-glycoprotein (P-gp), multidrug resistance (MDR)-associated protein (MRP), and major vault protein/lung resistance protein (LRP) in 141 children with acute lymphoblastic leukemia (ALL) and 27 with acute myeloid leukemia (AML) by flow cytometry. 9490695 1998
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 AlteredExpression disease BEFREE Clinical significance of P-glycoprotein (P-gp) expression in childhood acute lymphoblastic leukemia. Results of a 6-year prospective study. 10500775 1999
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 AlteredExpression disease BEFREE For moab UIC-2, P-gp expression levels were higher in AML than in ALL. 10897123 2000
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 AlteredExpression disease BEFREE In whole ALL, CD13/CD33 was associated closely with the presence of stem-cell antigen CD34, and in T-lineage ALL, CD13/CD33 had a significant correlation with additional stem-cell features, such as HLA-DR, multidrug resistance 1 (MDR1) and c-kit gene expression. 11531016 2001
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 AlteredExpression disease BEFREE This in vitro study suggests that bcr-abl-positive ALL is relatively resistant to daunorubicin, but this resistance is not mediated through mdr1 gene expression. 12410571 2002
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker disease BEFREE Overexpression of the multidrug resistance gene, MDR1, is of prognostic relevance in acute myeloid leukemia, while its role in acute lymphoblastic leukemia (ALL) is still under debate. 12851703 2003
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 AlteredExpression disease BEFREE Multiple drug resistance protein (MDR-1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) gene expression in childhood acute lymphoblastic leukemia. 15543372 2004
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker disease BEFREE To explore this phenomenon we investigated N6/ADR, a doxorubicin-selected, P-gp-positive variant of the human acute lymphoblastic leukemia (ALL) cell line NALM6. 14618619 2004
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 AlteredExpression disease BEFREE The expression of P-glycoprotein, multidrug-resistance protein, and lung-resistance protein (LRP) was not higher in infants compared to older c/preB ALL patients, but LRP was higher in proB ALL and MLL-rearranged ALL of all ages. 14712291 2004
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 GeneticVariation disease BEFREE In conclusion, the results of the present study provide evidence that C3435T MDR1 polymorphism may involve both the susceptibility to and the clinical outcome of childhood ALL. 15059065 2004
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 GeneticVariation disease BEFREE In a matched case-control study, we investigated the associations between CNS relapse in childhood ALL and the presence of phenotypically relevant single nucleotide polymorphisms within the GSTP1 (codon 105 and 114) and MDR1 genes (ABCB1; coding for Pgp; exon 26, C3435T). 15717687 2005
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 AlteredExpression disease BEFREE From this study, it is clear that P-gp/170 is expressed to a higher degree in leukemic cells and this is greater in relapsed compared to de novo cases and more in AML than ALL blasts. 16522547 2006
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 GeneticVariation disease BEFREE Buccal cell DNA from ALL cases (n = 294) and controls (n = 369) individually matched on gender, date of birth, Hispanic status, and maternal race were whole genome amplified and genotyped for four MDR1 SNPs, T-129C (rs3213619), C1236T (rs1128503), G2677T/A (rs2032582), and C3435T (rs1045642). 17548681 2007
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker disease BEFREE Expression of multidrug resistance 1 (MDR1), multidrug resistance-related protein 1 (MRP1), lung resistance protein (LRP), and breast cancer resistance protein (BCRP) genes and clinical outcome in childhood acute lymphoblastic leukemia. 17875533 2007
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 GeneticVariation disease BEFREE The present study suggests that the genetic background of MDR1 may be associated with the development of childhood ALL, possibly due to a quantitative change in the MDR1 gene resulting from genetic polymorphisms. 17568669 2007
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 GeneticVariation disease BEFREE To determine the influence of the MDR1 C3435T polymorphism on the development of childhood acute lymphoblastic leukemia (ALL), we studied 107 children with ALL and 111 healthy subjects. 19317599 2008
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 GeneticVariation disease BEFREE Sixteen single nucleotide polymorphisms (SNPs) (CYP3A4*1B A>G, CYP3A5*3 G>A, GSTP1 313 A>G, GSTM1 deletion, GSTT1 deletion, MDR1 exon 21 G>T/A, MDR1 exon 26 C>T, MTHFR 677 C>T, MTHFR 1298 A>C, NR3C1 1088 A>G, RFC 80 G>A, TPMT 238 G>C, TPMT 460 G>A, TPMT 719 A>G, VDR intron 8 G>A, VDR FokI T>C) that have been implicated in the pharmacogenetics of ALL therapy were analyzed by TotalPlex amplification and SNP genotyping. 18385010 2008
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker disease BEFREE There were no relations between the presence of P-gp, clinical characteristics (age, sex, hepatomegaly, and splenomegaly) and initial laboratory parameters (immunophenotype, white blood cells count, and serum lactate dehydrogenase) in ALL. 19564743 2009
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 AlteredExpression disease BEFREE In this study, we have shown that changes in the expression of MDR1 gene after short-term incubation of lymphoblasts with prednisolone may have prognostic value in pediatric de novo ALL patients. 19352661 2009