Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | AlteredExpression | disease | BEFREE | The Foxp3 expression was similar in ATL and HAMSS, but significantly higher in HAM-SS than AC-SS (p<0.05). p65 was expressed in LSG MNC nuclei from all SS patients and co-expressed with Foxp3. | 29600938 | 2018 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | However, the mechanisms of FOXP3 expression and its association with Treg-like characteristics in ATL remain unclear. | 26681759 | 2016 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Foxp3 is expressed in around 80% of ATL cases. | 24792037 | 2014 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Approximately 60% of ATL cases indeed harbor leukemic cells that express FoxP3, a key transcription factor for T(reg) cells. | 21347344 | 2011 | ||||
|
0.080 | Biomarker | disease | BEFREE | FoxP3+ regulatory T cells are distinct from leukemia cells in HTLV-1-associated adult T-cell leukemia. | 19544530 | 2009 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | We describe here different features in Foxp3 expression profile between normal and leukemic CD4(+)CD25(+) T cells, using peripheral blood samples from healthy controls (HCs), human T-cell leukemia virus type-1 (HTLV-1)-infected asymptomatic carriers (ACs), patients with adult T-cell leukemia (ATL), and various hematopoietic cell lines. | 18510697 | 2008 | ||||
|
0.080 | Biomarker | disease | BEFREE | These results indicate that Foxp3 expression is variable in ATL cases and that Foxp3-high ATL cells, which resemble Treg phenotypically as well as functionally, may be involved in immune suppression in ATL. | 16867905 | 2006 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Nevertheless, among the ATL cells that strongly expressed Foxp3, those from two of the five patients showed no apparent suppressive activity. | 16361311 | 2006 |