Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.090 | GeneticVariation | group | BEFREE | We generated and monitored liver tumor initiation in Mir122a-null Pten heterozygous (Mir122a<sup>-/-</sup>;Pten<sup>+/-</sup> and Mir122a<sup>-/-</sup>;Alb-Cre;Pten<sup>fx/+</sup>) mice and compared the results with those in Mir122a<sup>-/-</sup> mice. | 30165041 | 2018 | ||||
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0.090 | Biomarker | group | BEFREE | Lower serum miR-122 is a unique feature of HNF1A-DM patients and might partially explain the increased risk for liver neoplasm and abnormal lipid metabolism in HNF1A-DM patients. | 30155490 | 2018 | ||||
|
0.090 | Biomarker | group | BEFREE | The miR-122 actively targeted liver tumor cells and induced their apoptosis, including drug-resistant liver tumor cells. | 28114997 | 2017 | ||||
|
0.090 | AlteredExpression | group | BEFREE | Multiple studies have shown that miR-122 level is reduced in a variety of liver tumors and can be used as a specific marker for liver injury. | 27472451 | 2016 | ||||
|
0.090 | Biomarker | group | BEFREE | Additionally, delivery of miR-122 using a viral vector or liposomal nanoparticles resulted in liver tumor suppression in animal models. | 25537773 | 2015 | ||||
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0.090 | Biomarker | group | BEFREE | In summary, our results reveal a novel Hnf4α/miR-122/GALNT10 regulatory pathway that facilitates EGF miR-122 activation and hepatoma growth in HBV-associated hepatocarcinogenesis. | 25422324 | 2015 | ||||
|
0.090 | Biomarker | group | BEFREE | MicroRNA‑122 regulation of the morphology and cytoarchitecture of hepatoma carcinoma cells. | 24504483 | 2014 | ||||
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0.090 | AlteredExpression | group | BEFREE | Since miR-122 and miR-34a downregulation is a common feature in spontaneous human hepatocarcinoma, our finding that these miRNAs are able to target FUT8 3'UTR suggests that, together with transcriptional and other post-transcriptional systems, a miRNA-mediated mechanism could also be involved in the increased core fucosylation observed in liver tumors. | 24130780 | 2013 | ||||
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0.090 | Biomarker | group | BEFREE | The aim of this study was to investigate the effects of miR-122 on the viability and apoptosis of hepatoma cells.MATERIAL AND METHODS. | 19891584 | 2009 |