DMRs in genes such as RARB (FDR 1.1 × 10<sup>-19</sup> , mean change in beta [Δ] -0.09), GPR135 (FDR 1.87 × 10<sup>-8</sup> , mean Δ -0.09) and TPO (FDR 8.58 × 10<sup>-5</sup> , mean Δ -0.11), and DVMCs in NPTN, NRG2, GLT25D2 and TRPC3 (all with p <0.05, t-test) were significantly associated with asbestos exposure status in exposed versus non-exposed lung tumors.