| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | AlteredExpression | disease | BEFREE | On the basis of top differentially expressed genes between SLE and healthy controls, SLE patients with high levels of serum IFNβ clustered together while SLE patients with low levels of IFNβ clustered with healthy controls. | 31153744 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Here, we discuss data supporting a new concept that the production of type I IFN, especially IFNβ, by early stage transitional B cells may be an important source of type I IFN to support autoreactive B cell development in lupus. | 29466691 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Together, the results identify type I IFN-producing and -responding subpopulations within the SLE B cell compartment and suggest that some patients may benefit from specific targeting of IFN-β. | 30201809 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | This study demonstrates a novel pathway for elevated IFNβ signaling in SLE that is not dependent on stimulation by immune complexes but rather is cell intrinsic and critically mediated by IFNβ and MAVS, implicating new pathways as potential therapeutic targets. | 28471483 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | Here, we first used DNA microarray analysis to identify IFN-β-inducible genes in vitro and then used this set of genes to define an IFN-inducible transcriptional signature in peripheral blood mononuclear cells from a group of active systemic lupus erythematosus patients (n = 25). | 24561305 | 2014 | ||||
|
0.080 | Biomarker | disease | BEFREE | Modular repertoire analysis reveals complex IFN signatures in SLE, which are not restricted to the previous IFNα signature, but which also involve IFNβ and IFNγ. | 24644022 | 2014 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | IFNβ induced higher levels of the IFN-I-dependent MxA protein mRNA in SLE than in healthy controls, whereas the opposite was observed for SOCS1. | 22859983 | 2012 | ||||
|
0.080 | AlteredExpression | disease | LHGDN | Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus. | 17968925 | 2007 |