TRBV20OR9-2
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunoglobulin heavy chain (IgH) or T-cell receptor (TCR) gene rearrangement is observed in B-cell or T-cell primary vitreoretinal lymphoma, respectively.
|
22834783 |
2012 |
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We show that, in a line of TCR transgenic TG-B mice, an insertional mutation in one allele of the Epm2a locus and epigenetic silencing of another led to a high rate of lymphoma with early onset.
|
16959610 |
2006 |
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
group |
BEFREE |
CD43 antigen was positive, and rearrangement of TCR-beta gene was observed.The lymphoma was the T-cell type.
|
8127156 |
1994 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
group |
BEFREE |
T-cell receptor delta (TCR-delta) gene rearrangement was studied in 40 cases of acute leukaemia and lymphoma of T-cell lineage at diagnosis.
|
8756082 |
1996 |
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Nine patients had acute lymphoblastic leukaemia (T-ALL), nine patients had prolymphocytic leukaemia (PLL), six patients presented with a T-CLL/T-lymphocytosis syndrome, two patients had Sezary syndrome (SS) and one patient had HTLV-I positive T-cell leukaemia/lymphoma (ATLL). alpha TCR gene rearrangement could be demonstrated by the use of three available probes in only one case.
|
2961364 |
1987 |
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Incorporating the results of immunoglobulin heavy chain (IgH) and T-cell receptor (TCR) gene rearrangements enabled diagnosis of lymphoma in 17 patients, including 5 of the 6 patients suspected to have NHL or an atypical lymphoid proliferation.
|
16533955 |
2006 |
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Neither DNA flow cytometry nor TCR gene rearrangement can predict the 15% to 19% of patients in whom a lymphoma will develop.
|
8288780 |
1994 |
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
group |
BEFREE |
To identify such mixed-lineage lymphomas, we undertook a survey of 15 consecutive sinonasal lymphomas and found six with both a restricted KIR repertoire and a monoclonal TCR-gamma rearrangement, consistent with KIR(+) T-cell lymphomas.
|
12533686 |
2003 |
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Ten of 12 lymphomas tested showed clonal immunoglobulin (Ig) heavy chain gene rearrangements in the absence of clonal T-cell receptor (TCR) gene rearrangements.
|
10492077 |
1999 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
group |
BEFREE |
Characterization of lymphoma and gastritis areas of seven gastrectomy specimens using a T-cell receptor beta variable chain (TCR betaV) family-specific reverse transcriptase (RT)-polymerase chain reaction (PCR) assay and fluorescence-activated cell sorter (FACS) analysis revealed a local chronic and acute activation of T cells in lymphoma and an oligoclonal T-cell repertoire in gastritis and in lymphoma, partially sharing the same clones.
|
10565685 |
1999 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
group |
BEFREE |
We analyzed the organization of bcr, immunoglobulin and TCR genes in malignant lymphomas.
|
2160631 |
1990 |
TRBV20OR9-2
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Ig/TCR VDJ errors are also at the origin of recombinase mediated deregulated expression of a variety of proto-oncogenes in ALL, whereas in lymphoma it is increasingly clear that IgH containing translocations result from abnormalities other than VDJ errors (somatic hypermutation and/or isotype switching).
|
19731811 |
2009 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
group |
BEFREE |
The remaining 67 lymphomas had a germline beta-chain TCR-gene configuration.
|
2157671 |
1990 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
group |
BEFREE |
Strikingly, this unique TCR-independent killing is induced through lymphoma MHC-I engagement.
|
21753148 |
2011 |
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The clinicopathologic characteristics, immunophenotype, EBV in situ hybridization, and T cell receptor (TCR) gene rearrangement of primary pulmonary NK cell lymphoma from a 73-year-old Chinese woman were investigated and the clonal status was determined using female X-chromosomal inactivation mosaicism and polymorphisms at the phosphoglycerate kinase (PGK) gene.
|
23958352 |
2013 |
TRBV20OR9-2
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To study their cellular origin further, the authors analyzed T-cell receptor (TCR) gene transcription in three cases of nasal lymphomas and correlated the findings with the phenotype and gene rearrangement data.
|
8698315 |
1996 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
group |
BEFREE |
DNA studies of the lymphoma at the first presentation demonstrated dual rearrangement in the T-cell receptor beta (TCR beta) and immunoglobulin heavy chain J region (IgJH) genes.
|
8299098 |
1994 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
group |
BEFREE |
Five (25%) of the NK/T-cell phenotype lymphomas showed rearranged TCR gamma gene.
|
14989738 |
2004 |
TRBV20OR9-2
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This prompted us to investigate lymphoma biopsies from 7 non-Oriental patients with NTCL for the expression of natural killer (NK) and T-cell antigens, including TCR proteins, for the presence of EBV-encoded latent membrane protein (LMP) using immunohistochemistry and for the presence of EBV DNA and Epstein-Barr early region (EBER) RNA using in situ hybridization (ISH).
|
8387835 |
1993 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
group |
BEFREE |
Southern blot analysis of T cell receptor (TCR) gene rearrangements has proven to be a helpful tool to establish clonality in T cell leukemias and lymphomas.
|
10516765 |
1999 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
group |
BEFREE |
Sixty cases with a confirmed histological diagnosis of a T-cell lymphoproliferative disorder and TCR gamma GR were identified in our lymphoma registry from 1995 to 2001.
|
12707372 |
2003 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
group |
BEFREE |
EBV- TCR- lymphoma showed less necrosis (P = 0.0133) and a better 2-year survival rate (P = 0.0066) than EBV+ TCR- lymphoma.
|
15139996 |
2004 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
group |
BEFREE |
The predominant lymphoma types found in these 14 NBS children were diffuse large B cell lymphoma (DLBCL) and T cell lymphoblastic lymphoma (T-LBL/ALL), all showing monoclonal Ig/TCR rearrangements.
|
18788073 |
2008 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
group |
BEFREE |
Characterization of the clonality of non-Hodgkin's lymphoma (NHL) by the rearranged segments of immunoglobulin heavy chain (Ig(H)) or T cell receptor (TCR) genes is not only useful in the confirmation of the diagnosis but also for the future assessment of how a secondary lymphoma, such as a recurrence or another primary lymphoma, occurs.
|
10355963 |
1999 |
TRBV20OR9-2
|
0.100 |
Biomarker
|
group |
BEFREE |
Our current knowledge on the molecular and genetic basis of neoplastic transformation of lymphoid cells resulting in clinical phenotype of malignant lymphoma is further reviewed, and basic specific molecular mechanisms of Ig/TCR gene deregulation are presented, as well as recent achievements in molecular genetic profiling of malignant lymphoma.
|
12402389 |
2002 |