Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker group BEFREE Immunoglobulin heavy chain (IgH) or T-cell receptor (TCR) gene rearrangement is observed in B-cell or T-cell primary vitreoretinal lymphoma, respectively. 22834783 2012
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 GeneticVariation group BEFREE We show that, in a line of TCR transgenic TG-B mice, an insertional mutation in one allele of the Epm2a locus and epigenetic silencing of another led to a high rate of lymphoma with early onset. 16959610 2006
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 GeneticVariation group BEFREE CD43 antigen was positive, and rearrangement of TCR-beta gene was observed.The lymphoma was the T-cell type. 8127156 1994
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker group BEFREE T-cell receptor delta (TCR-delta) gene rearrangement was studied in 40 cases of acute leukaemia and lymphoma of T-cell lineage at diagnosis. 8756082 1996
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 GeneticVariation group BEFREE Nine patients had acute lymphoblastic leukaemia (T-ALL), nine patients had prolymphocytic leukaemia (PLL), six patients presented with a T-CLL/T-lymphocytosis syndrome, two patients had Sezary syndrome (SS) and one patient had HTLV-I positive T-cell leukaemia/lymphoma (ATLL). alpha TCR gene rearrangement could be demonstrated by the use of three available probes in only one case. 2961364 1987
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 GeneticVariation group BEFREE Incorporating the results of immunoglobulin heavy chain (IgH) and T-cell receptor (TCR) gene rearrangements enabled diagnosis of lymphoma in 17 patients, including 5 of the 6 patients suspected to have NHL or an atypical lymphoid proliferation. 16533955 2006
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 GeneticVariation group BEFREE Neither DNA flow cytometry nor TCR gene rearrangement can predict the 15% to 19% of patients in whom a lymphoma will develop. 8288780 1994
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 GeneticVariation group BEFREE To identify such mixed-lineage lymphomas, we undertook a survey of 15 consecutive sinonasal lymphomas and found six with both a restricted KIR repertoire and a monoclonal TCR-gamma rearrangement, consistent with KIR(+) T-cell lymphomas. 12533686 2003
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 GeneticVariation group BEFREE Ten of 12 lymphomas tested showed clonal immunoglobulin (Ig) heavy chain gene rearrangements in the absence of clonal T-cell receptor (TCR) gene rearrangements. 10492077 1999
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker group BEFREE Characterization of lymphoma and gastritis areas of seven gastrectomy specimens using a T-cell receptor beta variable chain (TCR betaV) family-specific reverse transcriptase (RT)-polymerase chain reaction (PCR) assay and fluorescence-activated cell sorter (FACS) analysis revealed a local chronic and acute activation of T cells in lymphoma and an oligoclonal T-cell repertoire in gastritis and in lymphoma, partially sharing the same clones. 10565685 1999
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker group BEFREE We analyzed the organization of bcr, immunoglobulin and TCR genes in malignant lymphomas. 2160631 1990
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 AlteredExpression group BEFREE Ig/TCR VDJ errors are also at the origin of recombinase mediated deregulated expression of a variety of proto-oncogenes in ALL, whereas in lymphoma it is increasingly clear that IgH containing translocations result from abnormalities other than VDJ errors (somatic hypermutation and/or isotype switching). 19731811 2009
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker group BEFREE The remaining 67 lymphomas had a germline beta-chain TCR-gene configuration. 2157671 1990
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker group BEFREE Strikingly, this unique TCR-independent killing is induced through lymphoma MHC-I engagement. 21753148 2011
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 GeneticVariation group BEFREE The clinicopathologic characteristics, immunophenotype, EBV in situ hybridization, and T cell receptor (TCR) gene rearrangement of primary pulmonary NK cell lymphoma from a 73-year-old Chinese woman were investigated and the clonal status was determined using female X-chromosomal inactivation mosaicism and polymorphisms at the phosphoglycerate kinase (PGK) gene. 23958352 2013
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 AlteredExpression group BEFREE To study their cellular origin further, the authors analyzed T-cell receptor (TCR) gene transcription in three cases of nasal lymphomas and correlated the findings with the phenotype and gene rearrangement data. 8698315 1996
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker group BEFREE DNA studies of the lymphoma at the first presentation demonstrated dual rearrangement in the T-cell receptor beta (TCR beta) and immunoglobulin heavy chain J region (IgJH) genes. 8299098 1994
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker group BEFREE Five (25%) of the NK/T-cell phenotype lymphomas showed rearranged TCR gamma gene. 14989738 2004
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 AlteredExpression group BEFREE This prompted us to investigate lymphoma biopsies from 7 non-Oriental patients with NTCL for the expression of natural killer (NK) and T-cell antigens, including TCR proteins, for the presence of EBV-encoded latent membrane protein (LMP) using immunohistochemistry and for the presence of EBV DNA and Epstein-Barr early region (EBER) RNA using in situ hybridization (ISH). 8387835 1993
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker group BEFREE Southern blot analysis of T cell receptor (TCR) gene rearrangements has proven to be a helpful tool to establish clonality in T cell leukemias and lymphomas. 10516765 1999
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker group BEFREE Sixty cases with a confirmed histological diagnosis of a T-cell lymphoproliferative disorder and TCR gamma GR were identified in our lymphoma registry from 1995 to 2001. 12707372 2003
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker group BEFREE EBV- TCR- lymphoma showed less necrosis (P = 0.0133) and a better 2-year survival rate (P = 0.0066) than EBV+ TCR- lymphoma. 15139996 2004
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker group BEFREE The predominant lymphoma types found in these 14 NBS children were diffuse large B cell lymphoma (DLBCL) and T cell lymphoblastic lymphoma (T-LBL/ALL), all showing monoclonal Ig/TCR rearrangements. 18788073 2008
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker group BEFREE Characterization of the clonality of non-Hodgkin's lymphoma (NHL) by the rearranged segments of immunoglobulin heavy chain (Ig(H)) or T cell receptor (TCR) genes is not only useful in the confirmation of the diagnosis but also for the future assessment of how a secondary lymphoma, such as a recurrence or another primary lymphoma, occurs. 10355963 1999
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.100 Biomarker group BEFREE Our current knowledge on the molecular and genetic basis of neoplastic transformation of lymphoid cells resulting in clinical phenotype of malignant lymphoma is further reviewed, and basic specific molecular mechanisms of Ig/TCR gene deregulation are presented, as well as recent achievements in molecular genetic profiling of malignant lymphoma. 12402389 2002