| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.360 | Biomarker | disease | BEFREE | Human single nucleotide polymorphisms SNPs associated with Knops blood group system; carried by complement receptor 1 may be associated with the pathology of P. falciparum malaria, and susceptibility to disease. | 24200236 | 2013 | ||||
|
0.360 | Biomarker | disease | BEFREE | Southeast Asian ovalocytosis (SAO), α(+)-thalassemia, and low expression of complement receptor 1 (CR1) have been associated with protection against severe Plasmodium falciparum malaria. | 20889874 | 2010 | ||||
|
0.360 | GeneticVariation | disease | BEFREE | Complement receptor 1 (CR1/CD35) levels on erythrocytes and related CR1 polymorphisms have been associated with response to falciparum malaria in populations inhabiting malaria-endemic regions. | 19480840 | 2009 | ||||
|
0.360 | Biomarker | disease | BEFREE | It has been hypothesized that the African alleles Sl2 and McCb of the Swain-Langley (Sl) and McCoy (McC) blood group antigens of the complement receptor 1 (CR1) may confer a survival advantage in the setting of Plasmodium falciparum malaria, but this has not been demonstrated. | 16277654 | 2005 | ||||
|
0.360 | GeneticVariation | disease | BEFREE | The Knops blood group antigen erythrocyte polymorphisms have been associated with reduced falciparum malaria-based in vitro rosette formation (putative malaria virulence factor). | 12847553 | 2003 | ||||
|
0.360 | Biomarker | disease | CTD_human | Localization of Knops system antigens in the long homologous repeats of complement receptor 1. | 11724985 | 2001 | ||||
|
0.360 | GeneticVariation | disease | BEFREE | To investigate the relationship between CR1 density polymorphism and disease severity, we typed 185 Thai patients with acute falciparum malaria (55 severe and 130 uncomplicated) for their genotypes of this polymorphism. | 11425154 | 2001 | ||||
|
0.360 | Biomarker | disease | CTD_human | P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1. | 9230440 | 1997 |