Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | AlteredExpression | disease | BEFREE | Hyper-activation of epidermal growth factor receptor (EGFR) signaling is characteristic of several different classes of human cancers, including a subset of glioblastoma and medulloblastoma. | 29574250 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | The multiply Cox regression suggested the overexpression and amplification of EGFR were negative prognostic factors for MB. | 24986561 | 2014 | ||||
|
0.070 | Biomarker | disease | BEFREE | Therefore, the simultaneous targeting of these oncogenic signaling components including wild-type EGFR, EGFRvIII mutant and hedgehog pathways may constitute a potential therapeutic approach of great clinical interest to eradicate BTICs and improve the efficacy of current clinical treatments by radiation and/or chemotherapy against aggressive and recurrent medulloblastomas and GBMs. | 21615592 | 2011 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | The overall expression of ERBBs suggests that ErbB2/ErbB4 heterodimers and ErbB4 homodimers may be major functional units of the ErbBs in MB, while ErbB2/ErbB3 heterodimers may play a more prominent role in addition to ErbB4-containing dimers in PA. | 19017278 | 2009 | ||||
|
0.070 | Biomarker | disease | BEFREE | The effects of the epidermal growth factor receptor (EGFR) inhibitor gefitinib on cell growth and signaling were evaluated in three medulloblastoma (MB) cell lines (D283, D341, Daoy), one supratentorial primitive neuroectodermal tumor cell line (PFSK), and four MB primary cultures. | 19033425 | 2009 | ||||
|
0.070 | Biomarker | disease | BEFREE | Low frequency of N-myc, C-myc, and epidermal grow factor receptor (EGFR) gene amplification (< 10%) has been reported in medulloblastoma. | 14758948 | 2004 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Finally, we show that ERBB2-dependent medulloblastoma cell invasion in vitro and prometastatic gene expression in vivo can be blocked using the ERBB tyrosine kinase inhibitor OSI-774. | 12517790 | 2003 |