|
SERPINE1
|
0.090 |
GeneticVariation
|
group |
BEFREE |
Two studies have reported that patients with the 4G/4G genotype of the plasminogen activator inhibitor-1 (PAI-1) genetic polymorphism had higher plasma PAI-1 concentrations and higher risk of death than those with the 4G/5G or 5G/5G genotypes; one study involved 175 children with meningococcal disease, and the other included 88 adult patients with septic shock.
|
26066833 |
2015 |
|
SERPINE1
|
0.090 |
GeneticVariation
|
group |
LHGDN |
Our data show a correlation between the 4G4G genotype of the PAI-1 gene and development of DIC in meningococcal infection.
|
17697137 |
2007 |
|
SERPINE1
|
0.090 |
GeneticVariation
|
group |
BEFREE |
Our data show a correlation between the 4G4G genotype of the PAI-1 gene and development of DIC in meningococcal infection.
|
17697137 |
2007 |
|
SERPINE1
|
0.090 |
GeneticVariation
|
group |
BEFREE |
Our data show a correlation between the 4G/4G genotype in the plasminogen activator inhibitor-1 gene and poor outcome in children with meningococcal infection.
|
15843979 |
2005 |
|
SERPINE1
|
0.090 |
GeneticVariation
|
group |
LHGDN |
The 4G/5G insertion/deletion promoter polymorphism, which leads to differences in PAI-1 production, has been demonstrated to affect the risk of developing severe complications and dying from sepsis during meningococcal infection and multiple trauma.
|
16237647 |
2005 |
|
SERPINE1
|
0.090 |
GeneticVariation
|
group |
BEFREE |
The 4G/5G insertion/deletion promoter polymorphism, which leads to differences in PAI-1 production, has been demonstrated to affect the risk of developing severe complications and dying from sepsis during meningococcal infection and multiple trauma.
|
16237647 |
2005 |
|
SERPINE1
|
0.090 |
GeneticVariation
|
group |
BEFREE |
Hence, the deletion polymorphism (4G) within the promoter region of the plasminogen activator inhibitor-1 gene leads to impaired fibrinolysis and influences the severity and outcome of meningococcal disease and the susceptibility to severe sepsis and multiple organ failure after trauma.
|
15118537 |
2004 |
|
SERPINE1
|
0.090 |
Biomarker
|
group |
BEFREE |
To assess the relevance of genetically determined host factors for the prognosis of meningococcal disease, Fc gamma receptor IIA (FcgammaRIIA), the tumor necrosis factor alpha (TNF-alpha) gene promoter region, and plasminogen-activator-inhibitor-1 (PAI-1) gene polymorphisms were studied in 145 patients with meningococcal disease and in 290 healthy controls matched by sex.
|
15243816 |
2004 |
|
SERPINE1
|
0.090 |
GeneticVariation
|
group |
BEFREE |
This study confirms that Caucasian pediatric patients carrying the functional PAI-1 4G/4G genotype are at an increased risk of developing vascular complications and dying from meningococcal disease.
|
14668616 |
2003 |
|
SERPINE1
|
0.090 |
GeneticVariation
|
group |
BEFREE |
Because we had no information on genotypes of patients who died, we also genotyped 183 first-degree relatives of a consecutive series of patients with meningococcal infection for the 4G/5G deletion/insertion polymorphism in the promoter region of the plasminogen-activator-inhibitor-1 gene (PAI-1).
|
10470701 |
1999 |
|
SERPINE1
|
0.090 |
GeneticVariation
|
group |
BEFREE |
The relation between meningococcal disease outcome, PAI-1 concentration, and PAI-1 genotype was investigated in 175 children with meningococcal disease (37 from Rotterdam, the Netherlands, and 138 from London, UK) and 226 controls (137 from Rotterdam, 89 from London).
|
10470700 |
1999 |