| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | GeneticVariation | group | BEFREE | Genetic variants associated with severity of meningococcal disease, including the IgG Fc receptor (FCγRII)-A484T, interleukin-10 (IL-10)-A1082G, -C819T, and -C627A, IL-4-C589T, mannose binding lectin-2 (MBL2)-A/O, -H/L, -P/Q, and -X/Y, toll-like receptor 2 (TLR2)-G2408A, TLR4-A12874G and -C13174T, and TLR9-T1237C and -T1486C were determined by real-time PCR (RT-PCR) for 271 HIV-infected subjects (median, 17 years). | 23595505 | 2013 | ||||
|
0.070 | GeneticVariation | group | BEFREE | We could not observe a significant influence of CD14 C-159T and TLR4 Asp299Gly polymorphisms on the risk of developing IMD in surviving meningococcal disease patients. | 19809507 | 2009 | ||||
|
0.070 | GeneticVariation | group | BEFREE | We conclude that TLR4 mutations represent a risk factor for meningococcal disease in this age group. | 16395111 | 2006 | ||||
|
0.070 | GeneticVariation | group | BEFREE | Using a method that obviates the confounding effect of linkage disequilibrium, we observed that rare heterozygous missense mutations of TLR4 contribute to the development of systemic meningococcal disease among white populations of the southern United Kingdom (P = 0.02; odds ratio 8.2). | 12730365 | 2003 | ||||
|
0.070 | GeneticVariation | group | BEFREE | Mutations that affect innate immune sensing may account for a substantial fraction of sepsis, and a highly significant excess of mutations in TLR4 has been identified in patients with systemic meningococcal disease. | 14620135 | 2003 | ||||
|
0.070 | Biomarker | group | BEFREE | Polymorphism of the Fc gamma receptors and interleukin-10 gene but not of the Toll-like receptor 4 may influence the development of meningococcal infection. | 12015458 | 2002 | ||||
|
0.070 | GeneticVariation | group | BEFREE | Therefore, this functional TLR4 polymorphism does not influence susceptibility to or severity of meningococcal disease. | 11494169 | 2001 |