DisGeNET - a database of gene-disease associations

Multiple Myeloma, C0026764

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Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Gene

Score _gda

Association Type

Type

Original DB

Sentence supporting the association

PMID

PMID Year

Entrez Id:	2261
Gene Symbol:	FGFR3

FGFR3

0.700

CausalMutation

disease

CGI

Entrez Id:	2261
Gene Symbol:	FGFR3

FGFR3

0.700

CausalMutation

disease

CLINVAR

Entrez Id:	595
Gene Symbol:	CCND1

CCND1

0.700

Biomarker

disease

HPO

Entrez Id:	51185
Gene Symbol:	CRBN

CRBN

0.600

CausalMutation

disease

CGI

Entrez Id:	4893
Gene Symbol:	NRAS

NRAS

0.500

CausalMutation

disease

CGI

Entrez Id:	3845
Gene Symbol:	KRAS

KRAS

0.500

CausalMutation

disease

CLINVAR

Entrez Id:	673
Gene Symbol:	BRAF

BRAF

0.500

CausalMutation

disease

CGI

Entrez Id:	3845
Gene Symbol:	KRAS

KRAS

0.500

CausalMutation

disease

CGI

Entrez Id:	3981
Gene Symbol:	LIG4

LIG4

0.410

Biomarker

disease

CTD_human

Entrez Id:	3981
Gene Symbol:	LIG4

LIG4

0.410

CausalMutation

disease

CLINVAR

Entrez Id:	3981
Gene Symbol:	LIG4

LIG4

0.410

Biomarker

disease

HPO

Entrez Id:	4609
Gene Symbol:	MYC

MYC

0.400

GenomicAlterations

disease

CGI

Entrez Id:	1031
Gene Symbol:	CDKN2C

CDKN2C

0.340

GenomicAlterations

disease

CGI

Entrez Id:	7403
Gene Symbol:	KDM6A

KDM6A

0.320

CausalMutation

disease

CGI

Entrez Id:	7403
Gene Symbol:	KDM6A

KDM6A

0.320

GenomicAlterations

disease

CGI

Entrez Id:	330
Gene Symbol:	BIRC3

BIRC3

0.320

CausalMutation

disease

CGI

Entrez Id:	4094
Gene Symbol:	MAF

MAF

0.300

Biomarker

disease

MGD

Entrez Id:	8085
Gene Symbol:	KMT2D

KMT2D

0.180

GeneticVariation

disease

CLINVAR

Entrez Id:	2629
Gene Symbol:	GBA

GBA

0.110

Biomarker

disease

HPO

Entrez Id:	11200
Gene Symbol:	CHEK2

CHEK2

0.100

CausalMutation

disease

CLINVAR

Entrez Id:	6906
Gene Symbol:	SERPINA7

SERPINA7

0.010

Biomarker

disease

BEFREE

TBG t1/2 was 2.5 days in a patient with multiple myeloma and 3.6 days in two patients with thyrotoxicosis.

56342

1976

Entrez Id:	923
Gene Symbol:	CD6

CD6

0.020

Biomarker

disease

BEFREE

The tumor lacked two marker chromosomes, reciprocal translocation [rcp t(12; 15)], that in previous studies were found to be common to 3 other uncultured myelomas and 1 cultured mouse myeloma.

276632

1978

Entrez Id:	3565
Gene Symbol:	IL4

IL4

0.070

Biomarker

disease

BEFREE

To examine the resulting composite S mu-S epsilon junctions of human lymphoid cells, we have used a polymerase chain reaction strategy to clone the switch regions of the human myeloma U266 and of two IgE-producing human cell lines generated by treatment of lymphocytes with EBV plus IL-4.

1321850

1992