|
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The HLA-DQB1*06:02 allele alone was not sufficient to cause MS patients to develop narcolepsy.
|
28658402 |
2017 |
|
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The association of HLA-DRB1 and HLA-DQB1 alleles with genetic susceptibility to multiple sclerosis in the Slovak population.
|
26744784 |
2015 |
|
HLA-DQB1
|
0.400 |
Biomarker
|
disease |
BEFREE |
The effect observed was found to be strongest among the HLA-DQB1*0602-positive subjects, which implies genetic heterogeneity of MS. Meta-analysis of all published datasets supports increased risk of MS for the ICAM-1 Lys(469) homozygotes (relative risk = 1.3, p = 0.002).
|
12590979 |
2003 |
|
HLA-DQB1
|
0.400 |
Biomarker
|
disease |
BEFREE |
The frequencies of HLA-DRB1 * 1501, HLA-DRB5 * 0101, HLA-DRB3 * 0301, and HLA-DQB1* 0602 were not as high in Korean children with multiple sclerosis as in western children.
|
15201511 |
2004 |
|
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The frequency of HLA-DQB1*0402 allele was increased in NMO (p after Bonferroni correction, cp < 0.035) and the HLA-DRB1*15 and DQB1*06 alleles were increased in MS (cp < 0.0027, cp < 0.01), compared to controls.
|
21908482 |
2012 |
|
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The HLA-DRB1 and HLA-DQB1 alleles are associated with multiple sclerosis disability progression in Slovak population.
|
29619906 |
2018 |
|
HLA-DQB1
|
0.400 |
Biomarker
|
disease |
BEFREE |
The HLA-DRB1*1501- and HLA-DQB1*0602-Tg mice (MHC-II(-/-)), and control non-HLA-DR15-relevant-Tg mice were immunized with a set of overlapping PLP peptides or with recombinant soluble PLP for induction of "humanized" MS-like disease, as well as for ex-vivo analysis of immunogenic/immunodominant HLA-restricted T-cell epitopes and associated cytokine secretion profile.
|
22316121 |
2012 |
|
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The influence of the HLA-DRB1 and HLA-DQB1 allele heterogeneity on disease risk and severity in Iranian patients with multiple sclerosis.
|
22404765 |
2012 |
|
HLA-DQB1
|
0.400 |
Biomarker
|
disease |
BEFREE |
This new humanized model of MS further implicates autoimmunity against MOBP in MS pathogenesis, provides the first evidence of pathogenic HLA-DQ-associated anti-myelin autoimmunity, and is the first to offer a rationale for HLA-DQB1*0602 association with MS.
|
19648275 |
2009 |
|
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To verify whether HLA-DQA and HLA-DQB genes differed between unrelated (MSU) and related (MSR) patients, and whether relapsing-remitting and chronic progressive forms of MS are immunogenetically distinct entities.
|
8442703 |
1993 |