Expression level of linc-MAF-4 correlated with the annual relapse rate in patients with MS. Our results suggest that linc-MAF-4 is involved in the pathogenesis of MS, specifically via regulation of encephalitogenic T cells.-Zhang, F., Liu, G., Wei, C., Gao, C., Hao, J. Linc-MAF-4 regulates T<sub>h</sub>1/T<sub>h</sub>2 differentiation and is associated with the pathogenesis of multiple sclerosis by targeting MAF.