|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
05), total cholesterol (OR 1.35, 95% CI 1.11 to 1.65), plasminogen activator inhibitor-1 4G/4G (OR 1.72, 95% CI 1.20 to 2.45), and CRP levels >0.33 mg/L (OR 1.75, 95% CI 1.05 to 2.91) were all independently associated with a positive family history of myocardial infarction.
|
10634818 |
2000 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
AMI is associated with polymorphisms in the NOS3 and FGB but not in PAI-1 genes in young adults.
|
17126309 |
2007 |
|
SERPINE1
|
0.300 |
Biomarker
|
disease |
BEFREE |
Myocardial infarction occurs with a similar 24 h pattern in the 4G/5G versions of plasminogen activator inhibitor-1.
|
19444746 |
2009 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism, coronary thrombosis, and myocardial infarction in middle-aged Finnish men who died suddenly.
|
10928474 |
2000 |
|
SERPINE1
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Plasminogen activator inhibitor-1 (PAI-1) activity post myocardial infarction: the role of acute phase reactants, insulin-like molecules and promoter (4G/5G) polymorphism in the PAI-1 gene.
|
12801613 |
2003 |
|
SERPINE1
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Plasminogen activator inhibitor-1 (PAI-1) activity post myocardial infarction: the role of acute phase reactants, insulin-like molecules and promoter (4G/5G) polymorphism in the PAI-1 gene.
|
12801613 |
2003 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
PAI-1 4G/4G genotype was the only independent variable (OR 2.67, 95%CI 1.43-4.96, P = 0.002) associated with MI in this regression model.
|
17721742 |
2008 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
PAI-1 4G/4G genotype was the only independent variable (OR 2.67, 95%CI 1.43-4.96, P = 0.002) associated with MI in this regression model.
|
17721742 |
2008 |
|
SERPINE1
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
PAI-1 activity levels were also determined in the men who suffered a premature myocardial infarction 4 months after their discharge.
|
8883280 |
1996 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Plasminogen activator inhibitor-1 4G/5G-polymorphism and factor V Q506 mutation are not associated with myocardial infarction in young men.
|
9863707 |
1998 |
|
SERPINE1
|
0.300 |
Biomarker
|
disease |
BEFREE |
Before PAI-1 can be regarded as a risk factor in the conventional epidemiological sense, its relationship to myocardial infarction must be demonstrated in prospective studies of healthy populations.
|
8578529 |
1995 |
|
SERPINE1
|
0.300 |
Biomarker
|
disease |
BEFREE |
Does long-term angiotensin converting enzyme inhibition affect the concentration of tissue-type plasminogen activator-plasminogen activator inhibitor-1 in the blood of patients with a previous myocardial infarction.
|
9285181 |
1997 |
|
SERPINE1
|
0.300 |
Biomarker
|
disease |
RGD |
Downregulated expression of plasminogen activator inhibitor-1 augments myocardial neovascularization and reduces cardiomyocyte apoptosis after acute myocardial infarction.
|
16053971 |
2005 |
|
SERPINE1
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Elevated circulating levels of plasminogen activator inhibitor-1, the principle inactivator of the fibrinolytic system, have been related to the development of myocardial infarction.
|
9134651 |
1997 |
|
SERPINE1
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Elevated levels of plasminogen activator inhibitor-1 (PAI-1) are associated with myocardial infarction and stroke, especially in patients with diabetes.
|
15956119 |
2005 |
|
SERPINE1
|
0.300 |
Biomarker
|
disease |
BEFREE |
Functional variants of angiotensin-1-converting enzyme (ACE), beta-fibrinogen, plasminogen activator inhibitor-1, methylenetetrahydrofolate reductase, glycoprotein Illa, and many apolipoprotein genes are considered excellent candidate risk factors for MI.
|
9649939 |
1998 |
|
SERPINE1
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Genetic control of PAI-1 expression has also been shown, involving a -675 4G/5G polymorphism, the 4G/4G genotype being associated with higher plasma PAI-1 levels; its proper influence on the development of myocardial infarction is still debated.
|
10980830 |
1999 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
GJA4 1019 C > T, MMP3 -1171delA, and SERPINE1 -668delG genotypes have been associated with the risk of incident myocardial infarction.
|
17719307 |
2007 |
|
SERPINE1
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here we provide evidence for an independent, etiological role of PAI-1 in myocardial infarction.
|
7892190 |
1995 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Homozygosity for the fibrinogen -455A allele was significantly associated with a decreased risk of myocardial infarction (OR 0.66, 95% CI 0.44 to 0.99, P=0.04), whereas the PAI-1 4G4G genotype was significantly associated with increased risk (OR 1.20, 95% CI 1.04 to 1.39, P=0.04).
|
11748101 |
2001 |
|
SERPINE1
|
0.300 |
Biomarker
|
disease |
LHGDN |
However, healthy persons and patients with previous myocardial infarction differed regarding coronary risk factors associated with PAI-1.
|
15678273 |
2005 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In a multiple logistic regression analysis, age (OR 1.02 [95%-CI: 1.00-1.05]), total cholesterol (OR 1.40 [95%-CI: 1.14-1.71]), C-reactive protein levels >0.33 mg/l (OR: 1.87 [95%-CI: 1.10-3.20]), plasminogen activator inhibitor-1 4G/4G (OR: 1.84 [95%-CI: 1.27-2.66]), and MTHFR TT genotype (OR 1.62 [95%-CI: 1.08-2.42]), were all associated with a family history of myocardial infarction.
|
10456448 |
1999 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In conclusion the PAI-1 gene polymorphism was found to have a gender specific role in the female MI patients.
|
21082259 |
2011 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In essence, tagging polymorphisms, including the 4G/5G polymorphism, and common haplotypes of the SERPINE1 gene region were not associated with MI in a German sample, and no compelling evidence was obtained for a relationship of the 4G/5G polymorphism to MI and coronary atherosclerosis in a meta-analysis.
|
20352162 |
2010 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In our study, the FXIII 34Leu allele was associated with a lower risk of MI (P = 0.009), however, the PAI-1 4G allele showed no interaction with this polymorphism.
|
10030380 |
1999 |