|
SERPINE1
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The adjusted odds ratio (OR) of MI was 1.9 (95% confidence interval [CI] 1.4-2.8) for men with a plasma PAI-1 activity level greater than the 90 th percentile value of referents.
|
12783120 |
2003 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
05), total cholesterol (OR 1.35, 95% CI 1.11 to 1.65), plasminogen activator inhibitor-1 4G/4G (OR 1.72, 95% CI 1.20 to 2.45), and CRP levels >0.33 mg/L (OR 1.75, 95% CI 1.05 to 2.91) were all independently associated with a positive family history of myocardial infarction.
|
10634818 |
2000 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Increased plasma levels of coagulation proteins such as fibrinogen and plasminogen activator inhibitor-1 (PAI-1) are associated with an increased risk of myocardial infarction.
|
10554707 |
1999 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Two are associated with thrombophilia (765 4G/5G and -844 A>G, in the promoter), risk of myocardial infarction and postoperative deep venous thrombosis related to higher than normal levels of PAI-1.
|
21663586 |
2011 |
|
SERPINE1
|
0.300 |
Biomarker
|
disease |
LHGDN |
Plasminogen activator inhibitor in patients with acute myocardial infarction and re-infarction in syndrome X.
|
11934213 |
2002 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
To examine interactions among the angiotensin converting enzyme (ACE) insertion/deletion, plasminogen activator inhibitor-1 (PAI-1) 4G/5G, and tissue plasminogen activator (t-PA) insertion/deletion gene polymorphisms on risk of myocardial infarction using data from 343 matched case-control pairs from the Physicians Health Study.
|
15119966 |
2004 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
MTHFRA1298C and PAI-1 deletions were most frequent genetic variants in risk groups for MI in patients with diabetes mellitus (value of odds ratio sequentially [OR] = 3.79, p = 0.06 and [OR] = 5 × 10(8), p = 0.000).
|
22752805 |
2012 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
SERPINE1 haplotypes are mildly associated with plasma levels of PAI-1 and with the risk of MI in nonsmokers.
|
17656673 |
2007 |
|
SERPINE1
|
0.300 |
Biomarker
|
disease |
BEFREE |
Functional variants of angiotensin-1-converting enzyme (ACE), beta-fibrinogen, plasminogen activator inhibitor-1, methylenetetrahydrofolate reductase, glycoprotein Illa, and many apolipoprotein genes are considered excellent candidate risk factors for MI.
|
9649939 |
1998 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism, coronary thrombosis, and myocardial infarction in middle-aged Finnish men who died suddenly.
|
10928474 |
2000 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The insertion/deletion polymorphism (4G/5G) in the promotor region of the plasminogen activator inhibitor 1 (PAI-1) gene has been associated with an increased risk of myocardial infarction.
|
10971410 |
2000 |
|
SERPINE1
|
0.300 |
Biomarker
|
disease |
BEFREE |
Independent predictors of death were PAI-1 rise and final Thrombolysis in Myocardial Infarction flow.
|
29972733 |
2018 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In our study, the FXIII 34Leu allele was associated with a lower risk of MI (P = 0.009), however, the PAI-1 4G allele showed no interaction with this polymorphism.
|
10030380 |
1999 |
|
SERPINE1
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Elevated circulating levels of plasminogen activator inhibitor-1, the principle inactivator of the fibrinolytic system, have been related to the development of myocardial infarction.
|
9134651 |
1997 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the angiotensin-converting enzyme (ACE) (insertion/deletion (I/D) in intron 16) and of the plasminogen activator inhibitor-1 (PAI-1) (promoter 4G/5G) genes have been linked with coronary heart disease (CHD) and/or myocardial infarction (MI).
|
11427204 |
2001 |
|
SERPINE1
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The 4G allele was associated with significantly higher PAI-1 levels in cases but not controls and, taken independently, did not modify the risk of MI (P=0.9).
|
14629464 |
2003 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The 4G allele of the PAI-1 -675(4G/5G) insertion/deletion promoter polymorphism has been associated with elevated plasma levels of PAI-1 and an increased risk of myocardial infarction.
|
20806116 |
2010 |
|
SERPINE1
|
0.300 |
Biomarker
|
disease |
BEFREE |
MPO and PAI-1 are shown to have a critical role in the LV response immediately after MI, as demonstrated by markedly delayed myocardial rupture in the MPO(-/-) and accelerated rupture in the PAI-1(-/-).
|
12615902 |
2003 |
|
SERPINE1
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here we provide evidence for an independent, etiological role of PAI-1 in myocardial infarction.
|
7892190 |
1995 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Our results showed that carriers of PAI-1 4G/5G genotype with myocardial infarction have increased odds of coronary artery occlusion more than 1.6 times in comparison to the carriers of homozygous genotypes.
|
26273123 |
2015 |
|
SERPINE1
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In summary our results suggest that the impairment of fibrinolytic activity resulting from elevated levels of PAI-1 antigen and activity and t-PA antigen is an independent variable in CDS associated with the premature occurrence of myocardial infarction in male patients with FH.
|
11253736 |
2001 |
|
SERPINE1
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The present study demonstrates that patients with AMI exhibit decreased miR-30b expression and elevated PAI-1 expression in the peripheral blood. miR-30b may therefore inhibit the damage to myocardial cells that occurs following AMI and protect myocardial cell function by targeting PAI-1 expression.
|
29805539 |
2018 |
|
SERPINE1
|
0.300 |
Biomarker
|
disease |
BEFREE |
Polymorphisms of GJA4 and CYBA and of PAI1 and MMP3 are associated with myocardial infarction (MI) in men and women, respectively.
|
16998253 |
2006 |
|
SERPINE1
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Plasminogen activator inhibitor-1 (PAI-1) activity post myocardial infarction: the role of acute phase reactants, insulin-like molecules and promoter (4G/5G) polymorphism in the PAI-1 gene.
|
12801613 |
2003 |
|
SERPINE1
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
GJA4 1019 C > T, MMP3 -1171delA, and SERPINE1 -668delG genotypes have been associated with the risk of incident myocardial infarction.
|
17719307 |
2007 |