Gene: STK11 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 GeneticVariation group BEFREE LKB1 is a serine-threonine protein kinase mutated in patients with an autosomal dominantly inherited cancer syndrome predisposing to multiple benign and malignant tumours, termed Peutz-Jeghers syndrome. 12829253 2003
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 GeneticVariation group BEFREE Peutz-Jeghers Syndrome (PJS) is a hereditary cancer predisposing syndrome caused by autosomal dominant mutations in the serine/threonine kinase 11 (STK11) gene and is associated with decreased life expectancy. 29720104 2018
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 GeneticVariation group CLINVAR Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome. 12865922 2003
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 CausalMutation group CLINVAR Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome. 12865922 2003
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 CausalMutation group CLINVAR High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome. 16287113 2005
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 GeneticVariation group CLINVAR An unusual case of sex cord tumor with annular tubules with malignant transformation in a patient with Peutz-Jeghers syndrome. 19952941 2010
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 CausalMutation group CLINVAR Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer. 9887330 1999
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 CausalMutation group CLINVAR Molecular and clinical characteristics in 46 families affected with Peutz-Jeghers syndrome. 17404884 2007
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 GeneticVariation group CLINVAR High prevalence of germline STK11 mutations in Hungarian Peutz-Jeghers Syndrome patients. 21118512 2010
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 GeneticVariation group CLINVAR Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. 19892943 2009
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 GeneticVariation group CLINVAR Cancer risks in LKB1 germline mutation carriers. 16407375 2006
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 GeneticVariation group CLINVAR STK11 genotyping and cancer risk in Peutz-Jeghers syndrome. 15863673 2005
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 CausalMutation group CLINVAR Two novel mutations and a new STK11/LKB1 gene isoform in Peutz-Jeghers patients. 12112668 2002
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 CausalMutation group CLINVAR Mutations in the human LKB1/STK11 gene. 16110486 2005
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 GeneticVariation group CLINVAR Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. 16707622 2006
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 CausalMutation group CLINVAR Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. 19892943 2009
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 CausalMutation group CLINVAR An LKB1 AT-AC intron mutation causes Peutz-Jeghers syndrome via splicing at noncanonical cryptic splice sites. 15608654 2005
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 GeneticVariation group CLINVAR Peutz-Jeghers families unlinked to STK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma. 11389158 2001
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 CausalMutation group CLINVAR STK11 genotyping and cancer risk in Peutz-Jeghers syndrome. 15863673 2005
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 CausalMutation group CLINVAR Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome. 9760200 1998
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 GeneticVariation group CLINVAR Relative frequency and morphology of cancers in STK11 mutation carriers. 15188174 2004
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 CausalMutation group CLINVAR A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. 9428765 1998
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 CausalMutation group CLINVAR Genetic defects underlying Peutz-Jeghers syndrome (PJS) and exclusion of the polarity-associated MARK/Par1 gene family as potential PJS candidates. 17924967 2007
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 GeneticVariation group CLINVAR Predicting the functional effect of amino acid substitutions and indels. 23056405 2012
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.120 GeneticVariation group CLINVAR Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer. 9887330 1999