Our aim was to assess the relation of serum soluble interleukin-2 receptor (sIL2R) levels and MDR1 gene expression on lymphocytes with nephrotic syndrome and its corticosteroids therapy.
The frequencies of MDR1G2677T/A GT, GA, TT+AA genotypes or T allele, MDR1C3435T TT genotype, and T allele genotype frequencies were significantly increased in NS group.
We undertook this study to examine the distribution of three most frequent MDR-1 exonic polymorphisms G3435C, G2677T/A and C1236T in patients with NS and control children to investigate their usefulness as markers of responsiveness of the disease to steroids.