Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5058
Gene Symbol: PAK1
PAK1
0.030 Biomarker disease BEFREE PAK1 inhibition also leads to attenuated mTORC1 but not mTORC2 signaling, suggesting that mTORC2/SGK1 and Rac1/PAK1 pathways are independently responsible for mTORC1 activation in NF2-deficient meningiomas. 26219339 2015
Entrez Id: 5058
Gene Symbol: PAK1
PAK1
0.030 Biomarker disease BEFREE Second, we used shRNAs to knockdown Pak1, 2, and 3 in NIH3T3 cells expressing a dominant-negative form of merlin, NF2(BBA) (NIH3T3/NF2(BBA)), and find that simultaneous knockdown of Pak1-3 in these cells significantly reduced their growth rates in vitro and inhibited their ability to form tumors in vivo. 18829550 2008
Entrez Id: 5058
Gene Symbol: PAK1
PAK1
0.030 Biomarker disease BEFREE A clue to the therapy of neurofibromatosis type 2: NF2/merlin is a PAK1 inhibitor. 15000491 2004