Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.080 | Biomarker | disease | BEFREE | The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor whose disruption causes obesity. | 31002796 | 2019 | ||||
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0.080 | AlteredExpression | disease | BEFREE | Since 5-HT2CR is a class A G protein-coupled receptor (GPCR), drug discovery efforts have traditionally pursued the activation of the receptor through synthetic ligands with agonists proposed for the treatment of obesity, substance use disorders and impulse control disorders while antagonists may add value for the treatment of anxiety, depression and schizophrenia. | 31288724 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Targeting the CXCL12-CXCR4/CXCR7 axis could lead to novel approaches for offsetting the effects of obesity on prostate cancer progression.<i></i>. | 28687617 | 2017 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | The G protein-coupled receptor GPR55 has been proposed as a new cannabinoid receptor associated with bone remodelling, nervous system excitability, vascular homeostasis as well as in several pathophysiological conditions including obesity and cancer. | 25970609 | 2015 | ||||
|
0.080 | Biomarker | disease | BEFREE | There is now considerable literature demonstrating a link between inhibitory guanine nucleotide-binding protein (G protein) and G protein-coupled receptor (GPCR) signaling in insulin-responsive tissues and the pathogenesis of obesity and T2DM. | 24946790 | 2014 | ||||
|
0.080 | Biomarker | disease | BEFREE | The melanocortin-4 receptor (MC4R) is a G-protein-coupled receptor (GPCR) that is expressed in the central nervous system and has a role in regulating feeding behavior, obesity, energy homeostasis, male erectile response, and blood pressure. | 20462274 | 2010 | ||||
|
0.080 | Biomarker | disease | BEFREE | GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity. | 18037923 | 2008 | ||||
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0.080 | GeneticVariation | disease | BEFREE | Inactivation of the gene encoding this G protein-coupled receptor causes obesity in mice. | 10903341 | 2000 |