Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | GeneticVariation | disease | BEFREE | Finally, an in vivo study showed that reduced P2X7 receptor function aggravates estrogen-withdrawal-induced bone loss, which is in line with the growing number of reports cementing the association between P2X7 receptor polymorphisms and development of osteoporosis and fracture risk. | 30954934 | 2019 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | The activation of P2X7 receptor can ameliorate osteoporosis by inducing a fine balance between osteoclastic resorption and osteoblastic bone formation. | 30317598 | 2019 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Single-gene variant analysis showed that the carriers of the CC genotype of P2X7R rs3751143 revealed an increased OP risk. | 28884379 | 2018 | ||||
|
0.090 | Biomarker | disease | BEFREE | P2X7 receptor regulates osteoclast function and bone loss in a mouse model of osteoporosis. | 29472582 | 2018 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | The findings suggest that the P2X7R rs3751143 functional polymorphism might contribute to OP susceptibility in Chinese postmenopausal women. | 28497417 | 2017 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | The purpose of this study was to determine whether genetic variation in the P2X7 receptor gene (P2RX7) is associated with decreased BMD and risk of osteoporosis in fracture patients. | 22776862 | 2013 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Functional polymorphisms in the P2X7 receptor gene are associated with osteoporosis. | 22707062 | 2013 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | A total of 1694 women (aged 45-58) participating in the Danish Osteoporosis Prevention Study were genotyped for 12 functional P2X7 receptor variants. | 22274585 | 2012 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Certain polymorphic variants of P2RX7 may identify women at greater risk of developing osteoporosis. | 22234152 | 2012 |