Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.740 | Biomarker | disease | BEFREE | These data indicate that the activation of ATM-Chk2 checkpoint pathway and autophagy may contribute to Licochalcone A-induced anti-proliferating effect in osteosarcoma cell lines. | 31269698 | 2019 | ||||
|
0.740 | Biomarker | disease | BEFREE | Piperine inhibited osteosarcoma cell proliferation by causing G2/M phase cell cycle arrest associated with decreased expression of cyclin B1 and increased phosphorylation of Cyclin-dependent kinase-1(CDK1) and checkpoint kinase 2 (Chk2). | 25479727 | 2015 | ||||
|
0.740 | Biomarker | disease | BEFREE | These findings demonstrate that demethylation with 5-Aza-CdR increases radiosensitivity in some osteosarcoma cells through arresting cells at G2/M phase and increasing apoptosis, which is partly mediated by upregulation of 14-3-3σ, CHK2, and DAPK-1 genes, suggesting that 5-Aza-CdR may be a potential radiosensitizer to improve the therapy effect in osteosarcoma. | 24474250 | 2014 | ||||
|
0.740 | GeneticVariation | disease | ORPHANET | These findings of CHK2 gene mutations are consistent with osteosarcoma being a defining tumor of Li-Fraumeni syndrome. | 11746983 | 2002 | ||||
|
0.740 | Biomarker | disease | CTD_human | These findings of CHK2 gene mutations are consistent with osteosarcoma being a defining tumor of Li-Fraumeni syndrome. | 11746983 | 2002 | ||||
|
0.740 | GeneticVariation | disease | LHGDN | These findings of CHK2 gene mutations are consistent with osteosarcoma being a defining tumor of Li-Fraumeni syndrome. | 11746983 | 2002 | ||||
|
0.740 | GeneticVariation | disease | BEFREE | These findings of CHK2 gene mutations are consistent with osteosarcoma being a defining tumor of Li-Fraumeni syndrome. | 11746983 | 2002 | ||||
|
0.740 | CausalMutation | disease | CLINVAR | |||||||
|
0.740 | GeneticVariation | disease | CLINVAR | |||||||
|
0.740 | Biomarker | disease | HPO | |||||||
|
0.740 | GeneticVariation | disease | UNIPROT | |||||||
|
0.740 | Biomarker | disease | GENOMICS_ENGLAND |