×
Entrez Id:
8533
Gene Symbol:
COPS3
COPS3
0.090
Biomarker
disease
BEFREE
The amplification of gene COPS3 is closely related to the development of osteosarcoma and hepatocellular carcinoma.
31509289
2019
×
Entrez Id:
8533
Gene Symbol:
COPS3
COPS3
0.090
Biomarker
disease
BEFREE
The effect of COPS3 on the metastasis of osteosarcoma cells was investigated by transwell, wound healing assays and animal studies.
29970115
2018
×
Entrez Id:
8533
Gene Symbol:
COPS3
COPS3
0.090
Biomarker
disease
BEFREE
The COPS3 gene has stimulating effect on cell proliferation and progression of osteosarcomas and related cells.
22631635
2012
×
Entrez Id:
8533
Gene Symbol:
COPS3
COPS3
0.090
Biomarker
disease
BEFREE
We conclude that these genes, including COPS3 and PMP22, are candidate oncogenes in 17p11.2-p12 of importance in osteosarcoma tumourigenesis.
22292074
2012
×
Entrez Id:
8533
Gene Symbol:
COPS3
COPS3
0.090
AlteredExpression
disease
BEFREE
Our results suggested that overexpression of the COPS3 gene might have important roles in metastasis of osteosarcoma cells.
21436869
2011
×
Entrez Id:
8533
Gene Symbol:
COPS3
COPS3
0.090
Biomarker
disease
BEFREE
Amplification of COPS3 , detected in 31% of the osteosarcomas , was strongly associated with large tumor size (P=.0009), but was not associated with age at diagnosis, site, sex, and tumor necrosis.
17366602
2007
×
Entrez Id:
8533
Gene Symbol:
COPS3
COPS3
0.090
AlteredExpression
disease
BEFREE
Overexpression of COPS3 has been linked to TP53 protein degradation and, being equivalent to TP53 mutation, the induction of genomic instability, which frequently occurs in high-grade osteosarcoma .
15325100
2004
×
Entrez Id:
8533
Gene Symbol:
COPS3
COPS3
0.090
Biomarker
disease
BEFREE
We conclude that PMP22 and COPS3 , and possibly also the three ESTs, are candidate amplification targets in 17p11.2 approximately p12 in osteosarcoma .
15193436
2004
×
Entrez Id:
8533
Gene Symbol:
COPS3
COPS3
0.090
AlteredExpression
disease
BEFREE
We present detailed analysis of TP53 mutations and MDM2 and COPS3 expression levels in a set of 23 OS .
12917637
2003