| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.160 | Biomarker | disease | BEFREE | In young huRANKL mice, denosumab and OPG-Fc each reduced trabecular osteoclast surfaces by 95% and increased bone density and volume. | 19016581 | 2009 | ||||
|
0.160 | AlteredExpression | disease | BEFREE | We conclude that osteosclerosis in IMF is associated with increased endothelial OPG expression without concomitant RANKL downregulation. | 15982347 | 2005 | ||||
|
0.160 | Biomarker | disease | BEFREE | The osteoclastogenesis inhibitory factor osteoprotegerin (OPG) seems to be regulated by TGF beta-1 and substantial involvement of OPG expression in the process of osteosclerosis in IMF has recently been suggested. | 15726648 | 2005 | ||||
|
0.160 | Biomarker | disease | BEFREE | Gene knockout experiments using such animal models have suggested the essential role of hematopoietic cell-derived transforming growth factor beta1 in inducing bone marrow fibrosis and stromal cell-derived osteoprotegerin in promoting osteosclerosis. | 16293880 | 2005 | ||||
|
0.160 | AlteredExpression | disease | LHGDN | Interleukin-11 as an osteoprotegerin-inducing factor in culture medium of blastic cells from a patient with acute megakaryocytic leukemia complicated with osteosclerosis. | 15307108 | 2004 | ||||
|
0.160 | AlteredExpression | disease | LHGDN | Osteosclerosis in idiopathic myelofibrosis is related to the overproduction of osteoprotegerin (OPG). | 15504545 | 2004 | ||||
|
0.160 | Biomarker | disease | BEFREE | These results suggest that osteosclerosis in IMF may be related to overproduction of OPG and enhanced level of OPG is not due to the effect of TGF-beta1 on the BMS cells. | 15504545 | 2004 | ||||
|
0.160 | Biomarker | disease | BEFREE | Interleukin-11 as an osteoprotegerin-inducing factor in culture medium of blastic cells from a patient with acute megakaryocytic leukemia complicated with osteosclerosis. | 15307108 | 2004 | ||||
|
0.160 | Biomarker | disease | HPO |