| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | The inhibition of P-glycoprotein (P-gp) was determined in vitro, and the respective sensitization of doxorubicin-resistant ovarian carcinoma overproducing P-gp was detected. | 31416138 | 2019 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Hypermethylation of the analyzed ABCB1 promoter region was significantly correlated with low levels of the ABCB1 transcript in tumors from a subset of patients with breast and ovarian carcinoma prior to chemotherapy but not following treatment. | 31173253 | 2019 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Lastly, it was discovered that ABCB1 and CASP2 levels associated with FIGO stage and that the CIT level associated with the time to progression of ovarian carcinoma patients (P<0.0001). | 23542236 | 2013 | ||||
|
0.080 | Biomarker | disease | BEFREE | We therefore investigated the sensitivity of human ovarian carcinoma cells and their P-gp expressing MDR variants to complement. | 19040611 | 2009 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Caveolin-1 expression in ovarian carcinoma is MDR1 independent. | 11863219 | 2002 | ||||
|
0.080 | Biomarker | disease | BEFREE | The ovarian carcinoma cell line SKOV3 transducted with a human multidrug resistance gene (mdr1) served as the drug resistant model (SKOV3/mdr1). | 11780384 | 2001 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | The expression of the MDR1 gene has been shown to correlate with tumor aggressiveness and oncogenic activation both in experimental tumor models and in human clinical specimens In order to verify whether this association also takes place in ovarian carcinoma, we studied tumor samples from 39 patients by means of immunohistochemistry for the overexpression of P-glycoprotein (MDR1), nm23, c-erb-B2 and p53. | 9216679 | 1997 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | P-glycoprotein expression in multidrug-resistant human ovarian carcinoma cell lines. | 2565764 | 1989 |