Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.380 | AlteredExpression | disease | LHGDN | Potential involvement of IL-8 and its receptors in the invasiveness of pancreatic cancer cells. | 12632066 | 2003 | ||||
|
0.380 | Biomarker | disease | LHGDN | Signal of proteinase-activated receptor-2 contributes to highly malignant potential of human pancreatic cancer by up-regulation of interleukin-8 release. | 16525644 | 2006 | ||||
|
0.380 | Biomarker | disease | BEFREE | Furthermore, activated PSCs might exacerbate malignant behavior of cancer cells via IL-8 because suppression of IL-8 signaling reduced pancreatic tumor growth and fibrosis <i>in vivo</i>. | 31695760 | 2019 | ||||
|
0.380 | Biomarker | disease | BEFREE | Together, our findings identify IL-8 as an important mediator in the gemcitabine-induced infiltration of macrophages within the pancreatic tumor microenvironment and suggest the requirement of additional mechanism(s) for macrophage polarization. | 30097594 | 2018 | ||||
|
0.380 | Biomarker | disease | CTD_human | Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer. | 18307536 | 2008 | ||||
|
0.380 | Biomarker | disease | LHGDN | GSK3 and PKB/Akt are associated with integrin-mediated regulation of PTHrP, IL-6 and IL-8 expression in FG pancreatic cancer cells. | 15609321 | 2005 | ||||
|
0.380 | AlteredExpression | disease | LHGDN | Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer. | 18307536 | 2008 | ||||
|
0.380 | Biomarker | disease | BEFREE | Interleukin-8 (IL-8) is an angiogenic factor that promotes growth of pancreatic tumors. | 16103072 | 2005 | ||||
|
0.380 | AlteredExpression | disease | BEFREE | Overexpression of IL-8 in pancreatic tumors is believed to promote tumor angiogenesis and to activate survival signaling pathways. | 27749658 | 2017 |