Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.360 | Biomarker | disease | BEFREE | We have previously demonstrated that anti-CD44s H4C4 or liposomal-delivered STAT3 inhibitor FLLL32 sensitized pancreatic cancer cells to radiotherapy through the elimination or inhibition of cancer stem cells (CSCs) and that HAb18G/CD147 promoted STAT3-mediated pancreatic tumor development by forming a signaling complex with CD44s. | 31312365 | 2019 | ||||
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0.360 | Biomarker | disease | BEFREE | This study has used the following in vitro and in vivo techniques for the investigation of exceptional anticancer drug FL118's efficacy in treatment of resistant pancreatic cancer: cell culture; immunoblotting analysis to test protein expression; DNA sub-G1 flow cytometry analyses to test cell death; MTT assay to test cell viability; pancreatic cancer stem cell assays (fluorescence microscopy tracing; matrigel assay; CD44-positive cell colony formation assay); human luciferase-labeled pancreatic tumor orthotopic animal model in vivo imaging; pancreatic cancer patient-derived xenograft (PDX) animal models; and toxicology studies with immune-competent BALB/cj mice and beagle dogs. | 30285798 | 2018 | ||||
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0.360 | AlteredExpression | disease | BEFREE | Moreover, in human pancreatic ductal adenocarcinoma (PDAC) tissues, the expression patterns of KLF4 and CD44 were mutually exclusive, and this inverse relationship was particularly striking in human metastatic pancreatic tumors and in autochthonous mouse models of PDAC. | 26880805 | 2016 | ||||
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0.360 | Biomarker | disease | BEFREE | Strategies to target CD44s cab be developed to block pancreatic tumor formation and post-radiotherapy recurrence in patients. | 24397969 | 2014 | ||||
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0.360 | Biomarker | disease | BEFREE | This study demonstrates a central role of Notch signalling pathway in pancreatic cancer pathogenesis and identifies an effective approach to inhibit selectively EMT and suppress tumorigenesis by eliminating pancreatic tumor initiating CD44+/EpCAM+ cells. | 23094026 | 2012 | ||||
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0.360 | Biomarker | disease | CTD_human | Establishment of clonal colony-forming assay for propagation of pancreatic cancer cells with stem cell properties. | 17446842 | 2007 | ||||
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0.360 | AlteredExpression | disease | BEFREE | Diagnostic application of CD44 variant expression in pancreatic juice for detection of pancreatic neoplasm. | 11501843 | 2001 |