| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.100 | GeneticVariation | group | BEFREE | The results of this study have shown an interaction of the IL-1 positive genotype with age, smoking and P. gingivalis which suggests that IL-1 genotype is a contributory but non-essential risk factor for periodontal disease progression in this population. | 11737511 | 2001 | ||||
|
0.100 | GeneticVariation | group | BEFREE | Analysis of these data suggests that the IL-1A(+4845) [1,1]/IL-1B(+3953) [2,2] genotype is associated with periodontal disease in this young population. | 11669478 | 2001 | ||||
|
0.100 | GeneticVariation | group | BEFREE | In this study, we tested the hypothesis that allele 2 of the IL-1A gene at position -889 might act to elevate levels of IL-1alpha protein in patients with periodontal disease. | 11145356 | 2000 | ||||
|
0.100 | GeneticVariation | group | BEFREE | It also confirmed that both IL-1 genotyping and smoking history provide objective risk factors for periodontal disease in a private practice environment. | 10711605 | 2000 | ||||
|
0.100 | Biomarker | group | BEFREE | Variations in the genes that regulate the interleukin-1 (IL-1) response have been associated with both periodontal disease and cardiovascular disease. | 10685360 | 1999 | ||||
|
0.100 | GeneticVariation | group | BEFREE | Knowledge of IL-1 genotype status would be important in developing a treatment plan and predicting tooth survival for a new patient who smokes and presents with periodontal disease, especially if restorative care is needed. | 10052770 | 1999 | ||||
|
0.100 | Biomarker | group | BEFREE | The results indicated that the IL-1 haplotype may be of limited value for the prognosis of periodontal disease progression following non-surgical periodontal therapy. | 10599909 | 1999 | ||||
|
0.100 | Biomarker | group | BEFREE | Porphyromonas gingivalis is now recognized as a major pathogen in the chronic inflammatory periodontal diseases and it has previously been reported that a crude LAP fraction from this organism could induce IL-1 and interleukin 6 (IL-6) synthesis. | 9846737 | 1998 | ||||
|
0.100 | Biomarker | group | BEFREE | These results demonstrate that IL-1 is produced and released locally in periodontal disease at concentrations sufficient to mediate tissue inflammation and bone resorption. | 2141875 | 1990 |