| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | Biomarker | disease | BEFREE | We hypothesized that the inflammasome activity may be a central pathway by which HO-1 controls pulmonary inflammation following alveolar hypoxia. | 31664855 | 2020 | ||||
|
0.370 | Biomarker | disease | BEFREE | Anti-inflammatory Effects of Heme Oxygenase-1 Depend on Adenosine A<sub>2A</sub>- and A<sub>2B</sub>-Receptor Signaling in Acute Pulmonary Inflammation. | 29326725 | 2017 | ||||
|
0.370 | Biomarker | disease | BEFREE | The potential therapeutic benefits may include the attenuation of LPS-induced pulmonary inflammation due to sclareol's effects on several pathways, including NF-κB, MAPKs and HO-1, as well as the regulation of antioxidant enzyme activity. | 28068646 | 2017 | ||||
|
0.370 | AlteredExpression | disease | BEFREE | SERPINB1 gene knockdown increased post-OALT lung injury and pulmonary inflammation. rSB1 administration dose-dependently reduced post-OALT lung injury and decreased pulmonary inflammation and oxidative stress with concomitant enhanced HO-1 and STAT3 protein expression. | 28427999 | 2017 | ||||
|
0.370 | Biomarker | disease | BEFREE | Further, HO-1 induction also decreased viral replication and lung inflammation, as evidenced by a reduced neutrophil infiltration into the airways, with diminished cytokine and chemokine production and reduced T cell function. | 28566367 | 2017 | ||||
|
0.370 | Biomarker | disease | CTD_human | After adjustment for potentially confounding factors, both cerebrovascular disorders and HO-1 gene L-allele carriers were significant and independent risk factors for pneumonia. | 16582079 | 2006 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | After adjustment for potentially confounding factors, both cerebrovascular disorders and HO-1 gene L-allele carriers were significant and independent risk factors for pneumonia. | 16582079 | 2006 | ||||
|
0.370 | Biomarker | disease | BEFREE | In the present study we used genetically engineered mice that express high levels of a human cDNA HO-1 transgene in lung epithelium to assess the effect of HO-1 on lung inflammation. | 12709566 | 2003 |