SERPINE1
|
0.100 |
Biomarker
|
disease |
BEFREE |
All animals were relatively recovered by 24 h. Intratracheal instillation of NH<sub>3</sub> (1%) caused early symptoms of ALI including airway hyperresponsiveness, neutrophilic lung inflammation and altered levels of coagulation factors (increased fibrinogen and PAI-1) and early biomarkers of ALI (IL-18, MMP-9, TGFβ) which was followed by increased deposition of newly produced collagen 14 days later.
|
31039646 |
2019 |
SERPINE1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our study reveals that p53-mediated induction of PAI-1 expression due to chronic CS exposure exacerbates lung inflammation through elaboration of CXCL1, CXCL2, and CXCR2.
|
26747783 |
2016 |
SERPINE1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Consistent with PCSE-induced lung injury, IAV infection increased p53, PAI-1 and apoptosis in AECs in association with pulmonary inflammation.
|
25932922 |
2015 |
SERPINE1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Particulate matter-induced lung inflammation increases systemic levels of PAI-1 and activates coagulation through distinct mechanisms.
|
21494547 |
2011 |
SERPINE1
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results indicate that PAI-1 is a critical mediator that controls the development of the early lung inflammation that is required for the activation of the later innate immune response necessary for the eradication of P aeruginosa from the distal airspaces of the lung.
|
21768189 |
2011 |
SERPINE1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We aimed to evaluate the effect of functionally relevant 4G/5G polymorphism of PAI-1 gene in pneumonia induced sepsis.
|
20429897 |
2010 |
SERPINE1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The 4G allele of the 4G/5G polymorphism of the PAI-1 gene is associated with higher PAI-1 levels and an increased incidence of hospitalizations for pneumonia.
|
19387177 |
2009 |
SERPINE1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
4G/5G plasminogen activator inhibitor-1 polymorphisms and haplotypes are associated with pneumonia.
|
17761618 |
2007 |
SERPINE1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Finally, the PAI-1 mutants were more effective in reducing the neutrophil elastase and cathepsin G activities in an in vivo model of lung inflammation than were their physiological inhibitors.
|
15131125 |
2004 |
SERPINE1
|
0.100 |
Biomarker
|
disease |
LHGDN |
Induction of PAI-1 by exposure of lung epithelial cells to uPA is a newly recognized pathway by which PAI-1 could regulate local fibrinolysis and urokinase-dependent cellular responses in the setting of lung inflammation or neoplasia.
|
12642587 |
2003 |