| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | Both p38 MAPK inhibitor and TXA demonstrated the ability to attenuate burn-induced DAMP release and lung inflammation. | 30589751 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | The p38 MAPK signaling pathway plays a key role in lung inflammation and the development of acute lung injury (ALI). | 30453148 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | However, blocking p38 MAPK signaling through the inhibitor SB203580 significantly suppressed the acute lung injury and excessive lung inflammation in vivo, consistent with the reduced expression of the NLRP3 inflammasome and IL‑1β and cleavage of caspase‑1. | 30152849 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | The p38 isoform most relevant to lung inflammation was p38α, and AZD7624 specifically inhibited p38α and p38β isoforms in human alveolar macrophages. | 29628759 | 2018 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | We hypothesized that p38 is activated during IRB and contributes to IRB-induced pulmonary inflammation. | 29974374 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Involvements of p38 MAPK and oxidative stress in the ozone-induced enhancement of AHR and pulmonary inflammation in an allergic asthma model. | 29284473 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | Together, these data establish the involvement of the p38-βTrCP-TTP-TNFα signaling axis in radiation-induced lung inflammation and identified p38 inhibition as a possible lung radioprotection strategy. | 28548957 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | AMs are central resident immune cells during S. pneumoniae infection and are the main source of early proinflammatory cytokine release. p38 MAPK holds a major role in pathogen-induced pulmonary cytokine release and is a potential molecular target to modulate overwhelming lung inflammation. | 18483419 | 2008 |