Gene: IRS2 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8660
Gene Symbol: IRS2
IRS2 		0.100 Biomarker disease BEFREE These results indicate that IRS‑2/PI3K signaling may be involved in the development of PCOS and the therapeutic effects of DMBG on PCOS. 28990055 2017
Entrez Id: 8660
Gene Symbol: IRS2
IRS2 		0.100 GeneticVariation disease BEFREE Our findings suggest that IRS-1 Gly972Arg polymorphism is associated with PCOS in the Caucasian ethnicity, and IRS-2 Gly1057Asp polymorphism is correlated with PCOS in the Asian ethnicity. 27098445 2016
Entrez Id: 8660
Gene Symbol: IRS2
IRS2 		0.100 GeneticVariation disease BEFREE We further investigated the effect of interaction of IRS-1 Gly972Arg and IRS-2 Gly1057Asp on the risk of PCOS and found that women carried IRS-1 Gly/Arg or IRS-2 Asp/Asp or carried both IRS-1 Gly/Arg and IRS-2 Asp/Asp had a much higher risk of PCOS compared with their counterpart, respectively (OR 2.49, 95% C.I. 25310961 2014
Entrez Id: 8660
Gene Symbol: IRS2
IRS2 		0.100 GeneticVariation disease BEFREE The aim of this study was undertaken to investigate association of IRS-1 and IRS-2 genes polymorphisms with PCOS by conducting a meta-analysis. 22523112 2012
Entrez Id: 8660
Gene Symbol: IRS2
IRS2 		0.100 GeneticVariation disease BEFREE No statistically significant differences in the prevalence of IRS-1 Gly972Arg or IRS-2 Gly1057Asp polymorphisms or any combination of both were observed between controls and PCOS patients (P > 0.02). 22205343 2012
Entrez Id: 8660
Gene Symbol: IRS2
IRS2 		0.100 GeneticVariation disease BEFREE This pharmacologic study in IRS-2 polymorphism may provide more information for preventing long-term complications in PCOS. 21801267 2011
Entrez Id: 8660
Gene Symbol: IRS2
IRS2 		0.100 Biomarker disease BEFREE Four insulin receptor (INSR) SNPs and three insulin receptor substrate 2 (IRS2) SNPs associated with PCOS were genotyped in the replication cohort. 21300347 2011
Entrez Id: 8660
Gene Symbol: IRS2
IRS2 		0.100 GeneticVariation disease BEFREE No statistically significant differences in genotypes or allele frequencies for IRS-2 polymorphism were observed between controls and PCOS women. 20210696 2010
Entrez Id: 8660
Gene Symbol: IRS2
IRS2 		0.100 GeneticVariation disease BEFREE The Gly972Arg in IRS-1 and Gly1057Asp in IRS-2 polymorphisms influence glucose homeostasis in premenopausal women, but are not associated with PCOS. 16037106 2005
Entrez Id: 8660
Gene Symbol: IRS2
IRS2 		0.100 Biomarker disease BEFREE Insulin signaling via IRS-2 was also decreased in myotubes from women with PCOS. 15613682 2005
Entrez Id: 8660
Gene Symbol: IRS2
IRS2 		0.100 GeneticVariation disease BEFREE These results suggest that the IRS-2 Gly(1057)Asp polymorphism influences blood glucose levels in nondiabetic white and African-American women with PCOS. 12213887 2002
Entrez Id: 8660
Gene Symbol: IRS2
IRS2 		0.100 GeneticVariation disease LHGDN These results suggest that the IRS-2 Gly(1057)Asp polymorphism influences blood glucose levels in nondiabetic white and African-American women with PCOS. 12213887 2002
Entrez Id: 8660
Gene Symbol: IRS2
IRS2 		0.100 Biomarker disease BEFREE The abundance of IRS-2 was significantly increased (P < 0.05) in PCOS skeletal muscle, suggesting a compensatory change. 11440917 2001
Entrez Id: 8660
Gene Symbol: IRS2
IRS2 		0.100 GeneticVariation disease BEFREE We conclude that polymorphic alleles of both IRS-1 and IRS-2, alone or in combination, may have a functional impact on the insulin-resistant component of PCOS. 11522686 2001