| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | group | BEFREE | We recommend future TSPO PET studies in psychosis patients to differentiate between clinical states and consider potential age-related effects. | 30503836 | 2019 | ||||
|
0.070 | AlteredExpression | group | BEFREE | We observed that participants on the psychosis spectrum with lower stress-induced dopamine release in PFC had significantly higher TSPO expression in hippocampus (β = -2.39, SE = 0.96, F(1,11) = 6.17, p = 0.030). | 30409695 | 2019 | ||||
|
0.070 | Biomarker | group | BEFREE | In this study, we investigated the link between mitochondrial 18 kDa translocator protein (TSPO) and structural brain characteristics (i.e. regional brain volume, cortical thickness, and hippocampal shape) in key brain regions such as dorsolateral prefrontal cortex and hippocampus of a large group of participants (N = 90) including individuals at clinical high risk (CHR) for psychosis, first-episode psychosis (mostly antipsychotic-naïve) patients, and healthy volunteers. | 29906515 | 2018 | ||||
|
0.070 | Biomarker | group | BEFREE | PubMed was searched for studies comparing patients with psychosis with healthy control subjects using second-generation TSPO radioligands. | 29653835 | 2018 | ||||
|
0.070 | Biomarker | group | BEFREE | Translocator protein 18 kDa (TSPO) has been used to assess neuroinflammatory processes in psychotic disorders. | 29398205 | 2018 | ||||
|
0.070 | GeneticVariation | group | BEFREE | We conducted the first in vivo study linking translocator protein 18 kDa (TSPO) expression and glutathione (a major brain antioxidant and a marker for redox status) in the medial prefrontal cortex (mPFC) of a relatively large sample of participants (N = 48) including 27 antipsychotic-naïve individuals at clinical high risk for psychosis and 21 matched healthy volunteers using high-resolution PET with TSPO radioligand, [<sup>18</sup>F]FEPPA, and 3T proton magnetic resonance spectroscopy (<sup>1</sup>H MRS). | 29748630 | 2018 | ||||
|
0.070 | GeneticVariation | group | BEFREE | The purpose of this study was to determine whether microglial activity, measured using translocator-protein positron emission tomography (PET) imaging, is increased in unmedicated persons presenting with subclinical symptoms indicating that they are at ultra high risk of psychosis and to determine whether microglial activity is elevated in schizophrenia after controlling for a translocator-specific genetic polymorphism. | 26472628 | 2016 |