Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 55906
Gene Symbol: ZC4H2
ZC4H2
0.100 Biomarker disease HPO
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.020 GeneticVariation disease BEFREE Haplotype reconstruction showed that haplotypes in VEGF and eNOS are significantly associated with different effects on RDS, BPD, IVH, and ROP in our population. 26172140 2015
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.020 Biomarker disease BEFREE The purpose of this review article is to highlight the importance of considering the temporal relationship of VEGF and lung development in human neonates and developmentally-appropriate animal models with RDS and BPD. 22394267 2012
Entrez Id: 7421
Gene Symbol: VDR
VDR
0.010 GeneticVariation disease BEFREE Association of vitamin D receptor gene FokI and TaqI polymorphisms and risk of RDS. 30760068 2019
Entrez Id: 114131
Gene Symbol: UCN3
UCN3
0.010 AlteredExpression disease BEFREE Decreased TTF1 expression, dysregulation of SPB and SPC transcription by TTF-1, and disordered proteolytic processing of Surfactant protein B precursor together potentially contribute to the disruption of surfactant homeostasis and NRDS in bovine clones. 29388718 2018
Entrez Id: 89910
Gene Symbol: UBE3B
UBE3B
0.100 Biomarker disease HPO
Entrez Id: 7273
Gene Symbol: TTN
TTN
0.010 Biomarker disease BEFREE The rate of RDS/TTN in infants was significantly higher and the lamellar body counts (LBCs) significantly lower in singleton pregnancies than that in twin pregnancies (P < .001). 29894780 2018
Entrez Id: 7270
Gene Symbol: TTF1
TTF1
0.010 AlteredExpression disease BEFREE Decreased TTF1 expression, dysregulation of SPB and SPC transcription by TTF-1, and disordered proteolytic processing of Surfactant protein B precursor together potentially contribute to the disruption of surfactant homeostasis and NRDS in bovine clones. 29388718 2018
Entrez Id: 7263
Gene Symbol: TST
TST
0.020 Biomarker disease BEFREE <b>Abbreviations:</b> bCPAP: bubble continuous positive airway pressure; CPAP: continuous positive airway pressure; ELBW: extremely low birthweight; FiO<sub>2</sub>: ratio of oxygen content in gas flow (%); IbCPAP: improvised bubble continuous positive airway pressure device; LBW: low birthweight; NNU: neonatal unit; PEEP: positive end expiratory pressure; politeCPAP: the newly developed commercial bCPAP machine; RDS: respiratory distress syndrome; SpO<sub>2</sub>, oxygen saturation level (%). 30957682 2019
Entrez Id: 7263
Gene Symbol: TST
TST
0.020 Biomarker disease BEFREE One hundred child patients with NRDS in Linyi Central Hospital were collected according to the diagnostic criteria for RDS in the Pediatrics, and randomly divided into the treatment group (n=50) and the control group (n=50) based on different therapeutic methods. 31258703 2019
Entrez Id: 4576
Gene Symbol: TRNT
TRNT
0.100 Biomarker disease HPO
Entrez Id: 9325
Gene Symbol: TRIP4
TRIP4
0.100 Biomarker disease HPO
Entrez Id: 54210
Gene Symbol: TREM1
TREM1
0.010 AlteredExpression disease BEFREE In this study, we show that TREM-1 (triggering receptor expressed on myeloid cells 1) is upregulated in hyperoxia-exposed neonatal murine lungs as well as in tracheal aspirates and lungs of human neonates with respiratory distress syndrome and BPD as an adaptive response to survival in hyperoxia. 30281332 2019
Entrez Id: 84231
Gene Symbol: TRAF7
TRAF7
0.100 Biomarker disease HPO
Entrez Id: 7139
Gene Symbol: TNNT2
TNNT2
0.300 Biomarker disease CTD_human Effect of patent ductus arteriosus and indomethacin treatment on serum cardiac troponin T levels in preterm infants with respiratory distress syndrome. 10789933 2000
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.020 GeneticVariation disease BEFREE Association between Interleukin-10-1082 G/A and Tumor Necrosis Factor-<b>α</b> 308 G/A Gene Polymorphisms and Respiratory Distress Syndrome in Iranian Preterm Infants. 28298812 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.020 GeneticVariation disease BEFREE Genetic polymorphisms in the cytokines interleukin (IL)-10, IL-8, and tumor necrosis factor (TNF) alpha, were studied in 342 white Italian newborns (112 without RDS, 66 prematurely born with RDS, and 164 infants born at term who were included as healthy controls). 17314689 2007
Entrez Id: 3371
Gene Symbol: TNC
TNC
0.010 AlteredExpression disease BEFREE Increased expression of tenascin-C mRNA was seen below the alveolar and bronchiolar epithelia in RDS and BPD. 11850444 2002
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.010 Biomarker disease BEFREE Moreover, C-A enhanced IL-10 expression and suppressed the expressions of TLR2 and TLR4, indicating that curcumin-aspirin derivative might hold therapeutic potential for early IRDS. 30511622 2018
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.010 AlteredExpression disease BEFREE Moreover, C-A enhanced IL-10 expression and suppressed the expressions of TLR2 and TLR4, indicating that curcumin-aspirin derivative might hold therapeutic potential for early IRDS. 30511622 2018
Entrez Id: 7052
Gene Symbol: TGM2
TGM2
0.010 GeneticVariation disease BEFREE Haplotypes reconstruction showed that SOD1 (GG) decreased the risk of RDS, IVH and ROP; SOD2 (GT) increased the risk of BPD and decreased the risk of RDS, IVH, and ROP; SOD3 (TGC) decreased the risk of BPD and IVH; and CAT (CTC) decreased the risk of RDS. 22958044 2012
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.020 Biomarker disease BEFREE Correlation between serum transforming growth factor β1, interleukin-6 and neonatal respiratory distress syndrome. 31258705 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.020 Biomarker disease BEFREE Monitoring the changes of serum BMP-7 and TGF-β1 is very important for treatment and prognosis assessment of the NRDS. 29077160 2017
Entrez Id: 6892
Gene Symbol: TAPBP
TAPBP
0.010 GeneticVariation disease BEFREE Controlling for patient characteristics and complexity of disease (comorbid intestinal atresia/perforation, necrotizing enterocolitis, and respiratory distress syndrome), we compared surgical outcomes (mortality, length of stay, and incidence of TPN cholestasis) by hospital volume based on quartile for gastroschisis cases treated per year. 28947327 2017
Entrez Id: 6729
Gene Symbol: SRP54
SRP54
0.100 Biomarker disease HPO