HLA-DQB1
|
0.400 |
Biomarker
|
disease |
BEFREE |
HLA class II typing for HLA-DRB1 and HLA-DQB1 was performed by oligonucleotide typing in 49 families.Six probands and two relatives had ATA.The relatives with ATA had SSc.
|
7980852 |
1994 |
HLA-DQB1
|
0.400 |
Biomarker
|
disease |
BEFREE |
The development of an anticentromere antibody response in patients with systemic sclerosis appears to require the presence of a polar amino acid at position 26 in the antigen-binding cleft of the HLA-DQB1 molecule.
|
1457282 |
1992 |
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The increase in DRB1*1502-DRB5*0102 haplotype supported the hypothesis of Reveille, et al that uncharged polar amino acid residue at position 30 of HLA-DQB1 allele was important for a-Scl-70 positive PSS because close association of the haplotype with DQB1*0601 was well established in Japanese; listed as a hypothetical candidate of PSS susceptible DQB1 allele.
|
8064726 |
1994 |
HLA-DQB1
|
0.400 |
Biomarker
|
disease |
BEFREE |
HLA-DQB1*0301 was significantly associated with SSc per se in all 3 ethnic groups; HLA-DRB1*11 correlated with the anti-topoisomerase I antibody response, and HLA-DRB1*01, DRB1*04, and DQB1*0501 with ACA.
|
11303306 |
2001 |
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Antifibrillarin, although an infrequent nucleolar autoantibody, is a marker for severe SSc, especially in blacks and males, and is strongly associated with a unique HLA haplotype, as well as with combinations of certain HLA-DQB1 alleles.
|
8670324 |
1996 |
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that genetic predisposition to the antitopo I response in PSS is associated most closely with the HLA-DQB1 locus.
|
1326003 |
1992 |
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To examine the role of HLA-DRB1 and HLA-DQB1 alleles in the susceptibility to systemic sclerosis (SSc) and its clinical expression in a Spanish population.
|
19884273 |
2009 |
HLA-DQB1
|
0.400 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.
|
20383147 |
2010 |
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Position 26 of the first domain of the HLA-DQB1 allele in post-silicone implant scleroderma.
|
8991984 |
1995 |
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in exons 2-4 for HLA-A, -B, -C loci, exon 2 for HLA-DRB1 and exons 2,3 for HLA-DQB1 were analyzed for association with PSS at allele and haplotype levels.
|
26161794 |
2015 |
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although many studies have analyzed HLA allele frequencies in several ethnic groups in patients with scleroderma (SSc), none has been done in French Caucasian patients and none has evaluated which one of the common amino acid sequences, (67)FLEDR(71), shared by HLA-DRB susceptibility alleles, or (71)TRAELDT(77), shared by HLA-DQB1 susceptibility alleles in SSc, was the most important to develop the disease.
|
22615829 |
2012 |
HLA-DQB1
|
0.400 |
Biomarker
|
disease |
BEFREE |
Association of HLA-DQB1*0501 with scleroderma and its clinical features in Chinese population.
|
24067471 |
2014 |
HLA-DQB1
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Within the HLA region, HLA-DQB1, HLA-DPA1/B1, and NOTCH4 associations with SSc are likely confined to specific auto-antibodies.
|
21779181 |
2011 |