Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 53637
Gene Symbol: S1PR5
S1PR5
0.300 Biomarker disease CTD_human An immediate relationship between dermal S1P5 expression and fibrotic processes leading to skin alterations, such as formative for SSc pathogenesis, is indicated but should be studied more profound in further investigations. 29033951 2017
Entrez Id: 53637
Gene Symbol: S1PR5
S1PR5
0.300 Biomarker disease CTD_human However, at the earlier 2-week point in time, the mRNA data of <i>pro-collagen type 1</i> and <i>SMAD7</i> indicate a pro-fibrotic S1P5 contribution in the applied SSc mouse model. 29033951 2017
Entrez Id: 53637
Gene Symbol: S1PR5
S1PR5
0.300 Biomarker disease CTD_human The sphingolipid sphingosine-1-phosphate (S1P) is elevated in the sera of SSc patients, and its receptor S1P5 is expressed in skin tissue. 29033951 2017
Entrez Id: 53637
Gene Symbol: S1PR5
S1PR5
0.300 Biomarker disease CTD_human Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study. 29033951 2017
Entrez Id: 53637
Gene Symbol: S1PR5
S1PR5
0.300 Biomarker disease CTD_human Therefore, this study is an initial step in understanding the role of S1P5-mediated effects during early stages of fibrogenesis, which may encourage the ongoing search for new therapeutic options for SSc patients. 29033951 2017
Entrez Id: 53637
Gene Symbol: S1PR5
S1PR5
0.300 Biomarker disease CTD_human Nevertheless, almost nothing is known about the dermatological contribution of S1P5 to inflammatory and pro-fibrotic processes leading to the pathological changes seen in SSc. 29033951 2017