| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | disease | BEFREE | An allelic loss of p53 at exon 4 was detected in five nonseminomas, whereas LOH of p53 at intron 6 occurred in one of the seminoma and two of the nonseminoma samples. | 20092957 | 2010 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Tumor tissue obtained from the propositus with the seminoma revealed loss of heterozygosity in the TP53 gene. | 10484981 | 1999 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | With two papers confirming the importance of excess p53 expression in determining GCC chemotherapy response, particularly in seminoma, the question of whether seminoma should be treated with different chemotherapy strategies re-emerges. | 9619364 | 1998 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Seminomas (S) and embryonal carcinoma (EC) components showed the most positive nuclear staining. p53 expression showed a significant inverse correlation with the stage of disease (P < 0.0003). | 9252698 | 1997 | ||||
|
0.080 | Biomarker | disease | BEFREE | Group one consisted of eleven cases (6 nonseminomatous germ cell tumors and 5 seminomas) in which tissue samples for DNA analysis were microdissected from paraffin block regions with elevated immunohistochemical staining for p53 protein. | 7609148 | 1995 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Seminoma and nonseminomatous germ cell tumor constituents revealed P53 expression via immunohistochemistry in 90% and 94% of the cases, respectively. | 8015085 | 1994 | ||||
|
0.080 | PosttranslationalModification | disease | BEFREE | The present study suggested that mutation of the p53 gene is involved in the development of human testicular seminoma as in the case of several other types of human cancers. | 8345605 | 1993 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Aberrant accumulation of the p53 protein was found among testicular tumours of all major histological types, although generally a higher percentage of positive cases and a higher proportion of p53 over-expressing nuclei within individual lesions was observed in embryonal carcinomas when compared with seminomas. | 1652567 | 1991 |