<i>Streptococcus pneumoniae</i> is a major cause of pneumonia, wherein infection of respiratory mucosa drives a robust influx of neutrophils.We have previously shown that <i>S. pneumoniae</i> infection of the respiratory epithelium induces the production of the 12-lipoxygenase (12-LOX)-dependent lipid inflammatory mediator hepoxilin A3, which promotes recruitment of neutrophils into the airways, tissue damage, and lethal septicemia.