| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | GeneticVariation | disease | BEFREE | A case-control method (488 septic patients and 527 healthy individuals) was carried out in this study to investigate the genetic relationship between CFH polymorphisms (rs3753394 C/T, rs1065489 G/T and rs1061170 C/T) and susceptibility to sepsis caused by bacterial infections in Chinese Han populations. | 31525397 | 2020 | ||||
|
0.070 | Biomarker | disease | BEFREE | FH6-7/Fc has previously been shown to enhance complement-dependent killing of, and facilitate bacterial clearance in, animal models of the Gram-negative pathogens <i>Haemophilus influenzae</i> and <i>Neisseria meningitidis</i> We hypothesized that activation of complement by FH6-7/Fc on the surface of Gram-positive bacteria such as <i>S. pyogenes</i> will enable professional phagocytes to eliminate the pathogen.We found that FH6-7/Fc alleviated <i>S. pyogenes-</i>induced sepsis in a transgenic mouse model expressing human FH (<i>S. pyogenes</i> binds FH in a human-specific manner). | 29084837 | 2017 | ||||
|
0.070 | Biomarker | disease | BEFREE | Of the 9 human STEC O26:H11/H- strains, two belonged to ST29 and were isolated from two children with HUS and renal failure with sepsis respectively. | 25758912 | 2015 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | In this study, protection against experimental sepsis caused by pneumococci carrying different PspC variants was evaluated by immunisation with the fH-binding fragment of PspC. | 21911026 | 2011 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | Homozygosity for the complement factor H Y402H polymorphism, which is thought to reduce complement inhibition, was associated with less frequent SIRS/sepsis (the adjusted odds ratio for the homozygous variant complement factor H Y402H [CC] carriers was 0.3, 95% confidence interval, 0.1-0.7, p = .005). | 20351616 | 2010 | ||||
|
0.070 | Biomarker | disease | BEFREE | Thus, human AM/AMBP-1 can be further developed as a safe and effective therapy for patients with established sepsis. | 19009024 | 2009 | ||||
|
0.070 | Biomarker | disease | BEFREE | Thus, modulation of vascular responsiveness to AM by AMBP-1 may provide a novel approach for the management of sepsis. | 12643861 | 2003 |