Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.380 | GeneticVariation | group | BEFREE | IL-1β has emerged as pivotal for promoting inflammation, particularly in autoinflammatory diseases, whereas IL-1α and the IL-36 subfamily are associated with skin diseases. | 31515542 | 2019 | ||||
|
0.380 | Biomarker | group | BEFREE | In this small trial we did not observe any effect of blocking IL-1 on clinical skin disease or biomarkers of IL-1 activity. | 30277862 | 2019 | ||||
|
0.380 | Biomarker | group | BEFREE | Interleukin (IL)-18 is a member of the IL-1 family cytokine that regulates immune responses and is implicated in various inflammatory skin diseases. | 29857000 | 2018 | ||||
|
0.380 | Biomarker | group | BEFREE | Several case reports and clinical trials have demonstrated the efficacy of IL-1 inhibition in the treatment of these skin disorders. | 28588486 | 2017 | ||||
|
0.380 | Biomarker | group | BEFREE | The Role of Interleukin-1 in Inflammatory and Malignant Human Skin Diseases and the Rationale for Targeting Interleukin-1 Alpha. | 27604144 | 2017 | ||||
|
0.380 | Biomarker | group | BEFREE | Null and missense mutations in the genes encoding interleukin (IL)-1 family (IL-1 and IL-36) anti-inflammatory receptor antagonist (Ra) cytokines can underlie the development of severe pustular dermatoses. | 25688670 | 2016 | ||||
|
0.380 | Biomarker | group | BEFREE | IL-33 is a novel IL-1 family member with a putative role in inflammatory skin disorders and a complex biology. | 25739051 | 2015 | ||||
|
0.380 | Biomarker | group | CTD_human | Toxicogenomic analysis of chlorine vapor-induced porcine skin injury. | 22533443 | 2012 | ||||
|
0.380 | Biomarker | group | BEFREE | In summary, dysregulated expression of novel agonistic and antagonistic IL-1 family member ligands can promote cutaneous inflammation, revealing potential novel targets for the treatment of inflammatory skin disorders. | 17908936 | 2007 | ||||
|
0.380 | Biomarker | group | CTD_human | Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population. | 16835338 | 2006 |