|
HLA-DRB1
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
GCA was mostly associated with class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostly associated with class I genes (HLA-B/MICA).
|
28277489 |
2017 |
|
HLA-DRB1
|
0.090 |
Biomarker
|
disease |
BEFREE |
Meanwhile, HLA-DRB-1*15:02, DQA-1*01:03, DQB-1*06:01, and DPB-1*09:01 as HLA class II were positively associated with IBD-TA (P = 0.004, P = 0.019, P = 0.019, and P = 0.002, respectively).
|
28449344 |
2017 |
|
HLA-DRB1
|
0.090 |
Biomarker
|
disease |
BEFREE |
A significant increase in the frequencies of DRB1(∗)07 (Pc<0.01, OR=3.44, CI: 2.15-5.52) was observed among TA patients compared with the control group.
|
25636572 |
2015 |
|
HLA-DRB1
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Compared with controls, the frequencies of A*3001 (p=0.048), B*5201 (p=0.025), and DRB1*1502 (p=0.046) alleles were significantly higher in TA patients, and the frequency of A*2602 was significantly lower in TA patients when compared with controls (p=0.047).
|
17428358 |
2007 |
|
HLA-DRB1
|
0.090 |
Biomarker
|
disease |
BEFREE |
To date, we have not determined whether or how the DRB1*1502 gene might be related to TD.
|
11993515 |
2002 |
|
HLA-DRB1
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The association of Takayasu arteritis with Amerindian and Asian HLA-DRB1 alleles (DRB1*1602 and DRB1*1001) in the Colombian mestizo patients reported here, and with HLA-B*3906 previously reported in Mexicans, suggest the possibility that some HLA and disease associations are markers for ethnicity of a population carrying a disease gene which is present in an admixed population with the disease.
|
10980348 |
2000 |
|
HLA-DRB1
|
0.090 |
Biomarker
|
disease |
BEFREE |
Takayasu arteritis is an uncommon condition in Mexican Mestizo, however, previous studies report association of the disease in this population with Human Leukocyte Antigen (HLA)-B39 and HLA-DRB1*1301.
|
9951813 |
1998 |
|
HLA-DRB1
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Takayasu arteritis in Mexicans is probably associated with the HLA-DR6 (DRB1*1301) gene.
|
9248846 |
1996 |
|
HLA-DRB1
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the combination or haplotype of HLA-Bw52-DRB1*1502-DRB5*0102-DQA1*0103-DQB1*0601 -DPA1*02-DPB1*0901 may confer susceptibility to Takayasu arteritis while another combination or haplotype of HLA-Bw54-DRB1*0405-DRB4*0101-DQA1*0301-DQB1++ +*0401 may confer resistance to the disease.
|
1350869 |
1992 |