PBMCs of patients with active TB disease contained elevated percentages of LDNs compared with those of H.D., with an increased expression of CD66b, CD33, CD15, and CD16 compared to NDNs.
Mycobacterial antigen driven activation of CD14++CD16- monocytes is a predictor of tuberculosis-associated immune reconstitution inflammatory syndrome.
We observed a small effect, in Ethiopians, of FCGR3B copy number, where deletion was more frequent in HIV-TB co-infected patients than those infected with HIV alone.
43: 335-347] suggests that a shift of the CD16(-) monocyte population toward a CD16(+) subpopulation may represent an immune evasion strategy that ultimately favors persistence of Mycobacterium tuberculosis.
These results show that tuberculosis patients have an augmented frequency of CD16(+) circulating monocytes which are more prone to produce TNF-α and to undergo cell death in response to M. tuberculosis infection.