Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1565
Gene Symbol: CYP2D6
CYP2D6
0.490 GeneticVariation disease GWASCAT Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations. 24528284 2015
Entrez Id: 1565
Gene Symbol: CYP2D6
CYP2D6
0.490 GeneticVariation disease BEFREE The impact of Cytochrome P450 CYP1A2, CYP2C9, CYP2C19 and CYP2D6 genes on suicide attempt and suicide risk-a European multicentre study on treatment-resistant major depressive disorder. 23081704 2014
Entrez Id: 1565
Gene Symbol: CYP2D6
CYP2D6
0.490 Biomarker disease PSYGENET The impact of Cytochrome P450 CYP1A2, CYP2C9, CYP2C19 and CYP2D6 genes on suicide attempt and suicide risk-a European multicentre study on treatment-resistant major depressive disorder. 23081704 2014
Entrez Id: 1565
Gene Symbol: CYP2D6
CYP2D6
0.490 Biomarker disease PSYGENET 47 patients with Major Depressive Disorder, treated with V 75 - 300 mg/day, underwent CYP2D6 genotyping using the INFINITI-CYP2D6 assay. 24660534 2014
Entrez Id: 1565
Gene Symbol: CYP2D6
CYP2D6
0.490 GeneticVariation disease BEFREE The objective of this study is to investigate the influence of the 5-HTTLPR (serotonin transporter-linked promoter region), cytochrome P450 2C19, and cytochrome P450 2D6 polymorphisms on escitalopram (ESC) and venlafaxine (VEN) responses in major depressive disorder. 24014145 2014
Entrez Id: 1565
Gene Symbol: CYP2D6
CYP2D6
0.490 Biomarker disease PSYGENET The objective of this study is to investigate the influence of the 5-HTTLPR (serotonin transporter-linked promoter region), cytochrome P450 2C19, and cytochrome P450 2D6 polymorphisms on escitalopram (ESC) and venlafaxine (VEN) responses in major depressive disorder. 24014145 2014
Entrez Id: 1565
Gene Symbol: CYP2D6
CYP2D6
0.490 Biomarker disease PSYGENET A total of 149 inpatients with a diagnosis of major depressive disorder at the Institute of Living, Hartford Hospital (CT, USA), were genotyped to detect altered alleles in the CYP2D6 gene. 23734807 2013
Entrez Id: 1565
Gene Symbol: CYP2D6
CYP2D6
0.490 Biomarker disease BEFREE Length of psychiatric hospitalization is correlated with CYP2D6 functional status in inpatients with major depressive disorder. 23734807 2013
Entrez Id: 1565
Gene Symbol: CYP2D6
CYP2D6
0.490 GeneticVariation disease BEFREE CYP2C9, CYP2C19 and CYP2D6 genotypes and clinical data were obtained for 150 consecutive, consenting hospital admissions with a diagnosis of major depressive disorder and who were treated with psychotropic medications. 21861666 2012
Entrez Id: 1565
Gene Symbol: CYP2D6
CYP2D6
0.490 Biomarker disease PSYGENET CYP2C9, CYP2C19 and CYP2D6 genotypes and clinical data were obtained for 150 consecutive, consenting hospital admissions with a diagnosis of major depressive disorder and who were treated with psychotropic medications. 21861666 2012
Entrez Id: 1565
Gene Symbol: CYP2D6
CYP2D6
0.490 GeneticVariation disease BEFREE The group of patients with intermediate CYP2D6 metabolism (0.5 SGD) had a significantly higher frequency of remitters from major depressive disorder during the 8-week treatment (p = 0.0001). 20350136 2010
Entrez Id: 1565
Gene Symbol: CYP2D6
CYP2D6
0.490 GeneticVariation disease BEFREE The risk of major depression in CYP2D6*4/*4 was not significantly different from extensive metabolizers (OR = 0.85; 95% CI: 0.36-2.00; p = 0.72). 19374513 2009
Entrez Id: 1565
Gene Symbol: CYP2D6
CYP2D6
0.490 GeneticVariation disease BEFREE We investigated the relationship between the CYP2D6 polymorphism and steady-state plasma concentration of venlafaxine (VEN) and its primary metabolite o-desmethylvenlafaxine (ODV) in elderly participants receiving venlafaxine-XR for major depression in order to explore the contribution of pharmacogenetics to medication tolerability. 16642541 2007
Entrez Id: 1565
Gene Symbol: CYP2D6
CYP2D6
0.490 GeneticVariation disease BEFREE This paper explores the link between CYP2D6 genotype and antidepressant-associated ADRs in outpatients being treated for major depression with either nortriptyline or fluoxetine. 14716707 2004
Entrez Id: 1565
Gene Symbol: CYP2D6
CYP2D6
0.490 Biomarker disease BEFREE The steady-state plasma concentrations of imipramine and desipramine were measured after a more than 2-week treatment with 0.39 to 1.39 mg/kg/day of imipramine hydrochloride in 28 Japanese patients with major depression who had been phenotyped simultaneously with mephenytoin (for CYP2C19-related status) and with metoprolol (for CYP2D6-related status) before initiating the antidepressant therapy. 8835703 1996