| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.100 | Biomarker | group | BEFREE | A recent study found that the delivery of circRNAs generated <i>in vitro</i> activates RIG-I-mediated innate immune responses and provides protection against viral infection. | 29230098 | 2017 | ||||
|
0.100 | Biomarker | group | BEFREE | RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection. | 28760668 | 2017 | ||||
|
0.100 | Biomarker | group | BEFREE | Previously, PFAS has been reported to modulate RIG-I activation during viral infection via deamidation. | 30987822 | 2019 | ||||
|
0.100 | Biomarker | group | BEFREE | The relative roles of the endosomal TLR3/7/8 versus the intracellular RNA helicases RIG-I and MDA5 in viral infection is much debated. | 21079690 | 2010 | ||||
|
0.100 | Biomarker | group | BEFREE | RIG-I and MDA5 are cytoplasmic DEX(D/H) helicase proteins that can induce signaling in response to RNA ligands, including those from viral infections. | 18411269 | 2008 | ||||
|
0.100 | Biomarker | group | BEFREE | Goose RIG-I functions in innate immunity against Newcastle disease virus infections. | 23063767 | 2013 | ||||
|
0.100 | Biomarker | group | BEFREE | This is critical for promoting the growth and survival of T lymphocytes as well as the regulation of the RIG-I helicase pathway for type I interferon production in response to viral infections. | 24816846 | 2014 | ||||
|
0.100 | AlteredExpression | group | BEFREE | RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of the pathogen-associated molecular patterns (PAMPs) in the form of viral double-stranded RNA (dsRNA) motifs to induce expression of type 1 interferons (IFN1) (IFNα and IFNβ) and other pro-inflammatory cytokines during the early stage of viral infection. | 31379819 | 2019 | ||||
|
0.100 | AlteredExpression | group | BEFREE | RIG-I-like receptors (RLRs) are expressed ubiquitously at low levels, and their expression is induced by treatment with type I interferon (IFN) or a viral infection. | 20950133 | 2011 |